Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother–child cohort in Guadeloupe.
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| Title: | Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother–child cohort in Guadeloupe. |
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| Authors: | Oulhote, Youssef1 (AUTHOR), Rouget, Florence2 (AUTHOR), Michineau, Léah3 (AUTHOR), Monfort, Christine3 (AUTHOR), Desrochers-Couture, Mireille4 (AUTHOR), Thomé, Jean-Pierre5 (AUTHOR), Kadhel, Philippe6 (AUTHOR), Multigner, Luc3 (AUTHOR), Cordier, Sylvaine3 (AUTHOR) sylvaine.cordier@inserm.fr, Muckle, Gina4 (AUTHOR) gina.muckle@psy.ulaval.ca |
| Source: | Environmental Health: A Global Access Science Source. 2/27/2023, Vol. 22 Issue 1, p1-13. 13p. |
| Subject Terms: | *Chlordecone, *Pollutants, Behavior disorders in children, Cognitive ability, Wechsler Adult Intelligence Scale, Reasoning in children, School children |
| Geographic Terms: | Guadeloupe, West Indies |
| Abstract: | Background: Chlordecone is a highly persistent organochlorine insecticide that was intensively used in banana fields in the French West Indies, resulting in a widespread contamination. Neurotoxicity of acute exposures in adults is well recognized, and empirical data suggests that prenatal exposure affects visual and fine motor developments during infancy and childhood, with greater susceptibility in boys. Objective: To assess the associations between pre- and postnatal exposures to chlordecone and cognitive and behavioral functions in school-aged children from Guadeloupe. Methods: We examined 576 children from the TIMOUN mother–child cohort in Guadeloupe at 7 years of age. Concentrations of chlordecone and other environmental contaminants were measured in cord- and children's blood at age 7 years. Cognitive abilities of children were assessed with the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing and internalizing problem behaviors documented with the Strengths and Difficulties Questionnaire (SDQ) completed by the child's mother. We estimated covariate-adjusted associations between cord- and 7-years chlordecone concentrations and child outcomes using structural equations modeling, and tested effect modification by sex. Results: Geometric means of blood chlordecone concentrations were 0.13 µg/L in cord blood and 0.06 µg/L in children's blood at age 7 years. A twofold increase in cord blood concentrations was associated with 0.05 standard deviation (SD) (95% Confidence Interval [CI]: 0.0, 0.10) higher internalizing problem scores, whereas 7-years chlordecone concentrations were associated with lower Full-Scale IQ scores (FSIQ) and greater externalized behavioral problem scores. A twofold increase in 7-year chlordecone concentrations was associated with a decrease of 0.67 point (95% CI: -1.13, -0.22) on FSIQ and an increase of 0.04 SD (95% CI: 0.0, 0.07) on externalizing problems. These associations with Cognitive abilities were driven by decreases in perceptive reasoning, working memory and verbal comprehension. Associations between 7-year exposure and perceptive reasoning, working memory, and the FSIQ were stronger in boys, whereas cord blood and child blood associations with internalizing problems were stronger in girls. Conclusions: These results suggests that cognitive abilities and externalizing behavior problems at school age are impaired by childhood, but not in utero, exposure to chlordecone, and that prenatal exposure is related to greater internalizing behavioral problems. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 162076148 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother–child cohort in Guadeloupe. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Oulhote%2C+Youssef%22">Oulhote, Youssef</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rouget%2C+Florence%22">Rouget, Florence</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michineau%2C+Léah%22">Michineau, Léah</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Monfort%2C+Christine%22">Monfort, Christine</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Desrochers-Couture%2C+Mireille%22">Desrochers-Couture, Mireille</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomé%2C+Jean-Pierre%22">Thomé, Jean-Pierre</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kadhel%2C+Philippe%22">Kadhel, Philippe</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Multigner%2C+Luc%22">Multigner, Luc</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cordier%2C+Sylvaine%22">Cordier, Sylvaine</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> sylvaine.cordier@inserm.fr</i><br /><searchLink fieldCode="AR" term="%22Muckle%2C+Gina%22">Muckle, Gina</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> gina.muckle@psy.ulaval.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 2/27/2023, Vol. 22 Issue 1, p1-13. 13p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Chlordecone%22">Chlordecone</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders+in+children%22">Behavior disorders in children</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Wechsler+Adult+Intelligence+Scale%22">Wechsler Adult Intelligence Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Reasoning+in+children%22">Reasoning in children</searchLink><br /><searchLink fieldCode="DE" term="%22School+children%22">School children</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Guadeloupe%22">Guadeloupe</searchLink><br /><searchLink fieldCode="DE" term="%22West+Indies%22">West Indies</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Chlordecone is a highly persistent organochlorine insecticide that was intensively used in banana fields in the French West Indies, resulting in a widespread contamination. Neurotoxicity of acute exposures in adults is well recognized, and empirical data suggests that prenatal exposure affects visual and fine motor developments during infancy and childhood, with greater susceptibility in boys. Objective: To assess the associations between pre- and postnatal exposures to chlordecone and cognitive and behavioral functions in school-aged children from Guadeloupe. Methods: We examined 576 children from the TIMOUN mother–child cohort in Guadeloupe at 7 years of age. Concentrations of chlordecone and other environmental contaminants were measured in cord- and children's blood at age 7 years. Cognitive abilities of children were assessed with the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing and internalizing problem behaviors documented with the Strengths and Difficulties Questionnaire (SDQ) completed by the child's mother. We estimated covariate-adjusted associations between cord- and 7-years chlordecone concentrations and child outcomes using structural equations modeling, and tested effect modification by sex. Results: Geometric means of blood chlordecone concentrations were 0.13 µg/L in cord blood and 0.06 µg/L in children's blood at age 7 years. A twofold increase in cord blood concentrations was associated with 0.05 standard deviation (SD) (95% Confidence Interval [CI]: 0.0, 0.10) higher internalizing problem scores, whereas 7-years chlordecone concentrations were associated with lower Full-Scale IQ scores (FSIQ) and greater externalized behavioral problem scores. A twofold increase in 7-year chlordecone concentrations was associated with a decrease of 0.67 point (95% CI: -1.13, -0.22) on FSIQ and an increase of 0.04 SD (95% CI: 0.0, 0.07) on externalizing problems. These associations with Cognitive abilities were driven by decreases in perceptive reasoning, working memory and verbal comprehension. Associations between 7-year exposure and perceptive reasoning, working memory, and the FSIQ were stronger in boys, whereas cord blood and child blood associations with internalizing problems were stronger in girls. Conclusions: These results suggests that cognitive abilities and externalizing behavior problems at school age are impaired by childhood, but not in utero, exposure to chlordecone, and that prenatal exposure is related to greater internalizing behavioral problems. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12940-023-00970-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Chlordecone Type: general – SubjectFull: Pollutants Type: general – SubjectFull: Behavior disorders in children Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: Wechsler Adult Intelligence Scale Type: general – SubjectFull: Reasoning in children Type: general – SubjectFull: School children Type: general – SubjectFull: Guadeloupe Type: general – SubjectFull: West Indies Type: general Titles: – TitleFull: Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother–child cohort in Guadeloupe. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Oulhote, Youssef – PersonEntity: Name: NameFull: Rouget, Florence – PersonEntity: Name: NameFull: Michineau, Léah – PersonEntity: Name: NameFull: Monfort, Christine – PersonEntity: Name: NameFull: Desrochers-Couture, Mireille – PersonEntity: Name: NameFull: Thomé, Jean-Pierre – PersonEntity: Name: NameFull: Kadhel, Philippe – PersonEntity: Name: NameFull: Multigner, Luc – PersonEntity: Name: NameFull: Cordier, Sylvaine – PersonEntity: Name: NameFull: Muckle, Gina IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 02 Text: 2/27/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 1476069X Numbering: – Type: volume Value: 22 – Type: issue Value: 1 Titles: – TitleFull: Environmental Health: A Global Access Science Source Type: main |
| ResultId | 1 |
