Antioxidant activity and total phenolic compounds of Commiphora gileadensis extracts obtained by ultrasonic‐assisted extraction, with monitoring antiaging and cytotoxicity activities.
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| Title: | Antioxidant activity and total phenolic compounds of Commiphora gileadensis extracts obtained by ultrasonic‐assisted extraction, with monitoring antiaging and cytotoxicity activities. |
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| Authors: | Ahmed, Hani1 (AUTHOR), Rashed, Marwan M. A.2 (AUTHOR), Almoiliqy, Marwan3,4 (AUTHOR), Abdalla, Mohammed5 (AUTHOR) mohamedabdalla@mahdi.edu.sd, Bashari, Mohanad6 (AUTHOR), Zaky, Mohamed Y.7,8 (AUTHOR), Hailin, Zhu1 (AUTHOR), Naji, Taha A. A.3 (AUTHOR), Eibaid, Ahmed9 (AUTHOR), Wang, Jinpeng10 (AUTHOR), Jiang, Li‐Ping1 (AUTHOR) lpjiang@ncu.edu.cn |
| Source: | Food Science & Nutrition. Jun2023, Vol. 11 Issue 6, p3506-3515. 10p. |
| Subject Terms: | *Phenols, Sound waves, Extracts, Antioxidants, Aging prevention, Plant phenols |
| Abstract: | Commiphora gileadensis (C. gileadensis) has been identified and linked with various health benefits and pharmaceutical potential for its phytochemical activities and chemical constituents. This study aimed to evaluate ultrasonic‐assisted extraction (USE) technique for total phenols content from C. gileadensis leaf compared to the hydrodistillation extraction (HDE). Our results showed that the USE operating conditions were identified as: MeOH·H2O solvent‐to‐fresh sample ratio of 80:20 (v/v); ultrasonic power/frequency at 150 W/20 kHz; and a temperature of 40 ± 1°C; subjected to acoustic waves intermittently for a calculated time (5 min) during the total programmed time of 12 min. The USE exhibited (118.71 ± 0.009 mg GAE/g DM) more amounts of all phenols than HDE (101.47 ± 0.005 mg GAE/g DM), and antioxidant (77.78 ± 0.73%, 75.27 ± 0.59% scavenging inhibition of DPPH), respectively. Anti‐aging and Cytotoxicity activities were investigated. The results of biological evaluations showed that the crude extracts of C. gileadensis significantly extended the replicative lifespan of K6001 yeast. In addition, in vitro cytotoxicity against the HepG2 cell line showed significant anticancer activity, and approximately 100 μg/mL is required to decrease viability compared with that of the control. This study is proven for a larger scale to extract and isolate compounds of C. gileadensis for potential utilization in the pharmaceutical industry. In conclusion, advanced methods afford an extract with high activity in the biological properties of the extract. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 164284331 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Antioxidant activity and total phenolic compounds of Commiphora gileadensis extracts obtained by ultrasonic‐assisted extraction, with monitoring antiaging and cytotoxicity activities. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ahmed%2C+Hani%22">Ahmed, Hani</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rashed%2C+Marwan+M%2E+A%2E%22">Rashed, Marwan M. A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almoiliqy%2C+Marwan%22">Almoiliqy, Marwan</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdalla%2C+Mohammed%22">Abdalla, Mohammed</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> mohamedabdalla@mahdi.edu.sd</i><br /><searchLink fieldCode="AR" term="%22Bashari%2C+Mohanad%22">Bashari, Mohanad</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaky%2C+Mohamed+Y%2E%22">Zaky, Mohamed Y.</searchLink><relatesTo>7,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hailin%2C+Zhu%22">Hailin, Zhu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naji%2C+Taha+A%2E+A%2E%22">Naji, Taha A. A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eibaid%2C+Ahmed%22">Eibaid, Ahmed</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jinpeng%22">Wang, Jinpeng</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Li‐Ping%22">Jiang, Li‐Ping</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lpjiang@ncu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Jun2023, Vol. 11 Issue 6, p3506-3515. 10p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Phenols%22">Phenols</searchLink><br /><searchLink fieldCode="DE" term="%22Sound+waves%22">Sound waves</searchLink><br /><searchLink fieldCode="DE" term="%22Extracts%22">Extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Aging+prevention%22">Aging prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+phenols%22">Plant phenols</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Commiphora gileadensis (C. gileadensis) has been identified and linked with various health benefits and pharmaceutical potential for its phytochemical activities and chemical constituents. This study aimed to evaluate ultrasonic‐assisted extraction (USE) technique for total phenols content from C. gileadensis leaf compared to the hydrodistillation extraction (HDE). Our results showed that the USE operating conditions were identified as: MeOH·H2O solvent‐to‐fresh sample ratio of 80:20 (v/v); ultrasonic power/frequency at 150 W/20 kHz; and a temperature of 40 ± 1°C; subjected to acoustic waves intermittently for a calculated time (5 min) during the total programmed time of 12 min. The USE exhibited (118.71 ± 0.009 mg GAE/g DM) more amounts of all phenols than HDE (101.47 ± 0.005 mg GAE/g DM), and antioxidant (77.78 ± 0.73%, 75.27 ± 0.59% scavenging inhibition of DPPH), respectively. Anti‐aging and Cytotoxicity activities were investigated. The results of biological evaluations showed that the crude extracts of C. gileadensis significantly extended the replicative lifespan of K6001 yeast. In addition, in vitro cytotoxicity against the HepG2 cell line showed significant anticancer activity, and approximately 100 μg/mL is required to decrease viability compared with that of the control. This study is proven for a larger scale to extract and isolate compounds of C. gileadensis for potential utilization in the pharmaceutical industry. In conclusion, advanced methods afford an extract with high activity in the biological properties of the extract. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/fsn3.3339 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 3506 Subjects: – SubjectFull: Phenols Type: general – SubjectFull: Sound waves Type: general – SubjectFull: Extracts Type: general – SubjectFull: Antioxidants Type: general – SubjectFull: Aging prevention Type: general – SubjectFull: Plant phenols Type: general Titles: – TitleFull: Antioxidant activity and total phenolic compounds of Commiphora gileadensis extracts obtained by ultrasonic‐assisted extraction, with monitoring antiaging and cytotoxicity activities. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ahmed, Hani – PersonEntity: Name: NameFull: Rashed, Marwan M. A. – PersonEntity: Name: NameFull: Almoiliqy, Marwan – PersonEntity: Name: NameFull: Abdalla, Mohammed – PersonEntity: Name: NameFull: Bashari, Mohanad – PersonEntity: Name: NameFull: Zaky, Mohamed Y. – PersonEntity: Name: NameFull: Hailin, Zhu – PersonEntity: Name: NameFull: Naji, Taha A. A. – PersonEntity: Name: NameFull: Eibaid, Ahmed – PersonEntity: Name: NameFull: Wang, Jinpeng – PersonEntity: Name: NameFull: Jiang, Li‐Ping IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20487177 Numbering: – Type: volume Value: 11 – Type: issue Value: 6 Titles: – TitleFull: Food Science & Nutrition Type: main |
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