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β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.

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Title: β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.
Authors: Serafín-Fabian, Jesús Isimar1 (AUTHOR), Elena Moreno-Godínez, Ma.2 (AUTHOR), Flores-Alfaro, Eugenia1 (AUTHOR), Parra-Rojas, Isela3 (AUTHOR), Rojas-García, Aurora Elizabeth4 (AUTHOR), Campos-Viguri, Gabriela Elizabeth5 (AUTHOR), Cahua-Pablo, José Ángel1 (AUTHOR), Ramírez-Vargas, Marco Antonio1,2 (AUTHOR) marvar@uagro.mx
Source: Environmental Toxicology & Pharmacology. Oct2023, Vol. 103, pN.PAG-N.PAG. 1p.
Subject Terms: *Pesticides, *Biomarkers, *Biological monitoring, Parasympatholytic agents, Sequential analysis, Poisoning, Occupational exposure
Abstract: The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides. This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels. A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed. Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels. The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure). [ABSTRACT FROM AUTHOR]
Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubTypeId: academicJournal
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  Data: β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Serafín-Fabian%2C+Jesús+Isimar%22">Serafín-Fabian, Jesús Isimar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elena+Moreno-Godínez%2C+Ma%2E%22">Elena Moreno-Godínez, Ma.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flores-Alfaro%2C+Eugenia%22">Flores-Alfaro, Eugenia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parra-Rojas%2C+Isela%22">Parra-Rojas, Isela</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rojas-García%2C+Aurora+Elizabeth%22">Rojas-García, Aurora Elizabeth</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campos-Viguri%2C+Gabriela+Elizabeth%22">Campos-Viguri, Gabriela Elizabeth</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cahua-Pablo%2C+José+Ángel%22">Cahua-Pablo, José Ángel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramírez-Vargas%2C+Marco+Antonio%22">Ramírez-Vargas, Marco Antonio</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> marvar@uagro.mx</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Toxicology+%26+Pharmacology%22">Environmental Toxicology & Pharmacology</searchLink>. Oct2023, Vol. 103, pN.PAG-N.PAG. 1p.
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  Data: *<searchLink fieldCode="DE" term="%22Pesticides%22">Pesticides</searchLink><br />*<searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br />*<searchLink fieldCode="DE" term="%22Biological+monitoring%22">Biological monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Parasympatholytic+agents%22">Parasympatholytic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Sequential+analysis%22">Sequential analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Poisoning%22">Poisoning</searchLink><br /><searchLink fieldCode="DE" term="%22Occupational+exposure%22">Occupational exposure</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides. This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels. A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed. Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels. The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.etap.2023.104279
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      – SubjectFull: Biological monitoring
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      – SubjectFull: Poisoning
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      – SubjectFull: Occupational exposure
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      – TitleFull: β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.
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              M: 10
              Text: Oct2023
              Type: published
              Y: 2023
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