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Occupational exposure to respirable crystalline silica and lung cancer: a systematic review of cut-off points.

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Title: Occupational exposure to respirable crystalline silica and lung cancer: a systematic review of cut-off points.
Authors: Rey-Brandariz, Julia1,2 (AUTHOR), Martínez, Cristina3,4 (AUTHOR), Candal-Pedreira, Cristina1,2,5 (AUTHOR), Pérez-Ríos, Mónica1,2,5 (AUTHOR), Varela-Lema, Leonor1,2,5 (AUTHOR), Ruano-Ravina, Alberto1,2,5 (AUTHOR) alberto.ruano@usc.es
Source: Environmental Health: A Global Access Science Source. 11/30/2023, Vol. 22 Issue 1, p1-12. 12p.
Subject Terms: Occupational exposure, Lung cancer, Silica, Disease risk factors, Cancer-related mortality
Abstract: Background: Respirable crystalline silica (RCS) is associated with the development of lung cancer. However, there is uncertainty around the exposure threshold at which exposure to RCS may pose a clear risk for the development of lung cancer. The objective of this study was to review the cut-off points at which the risk of mortality or incidence of lung cancer due to occupational exposure to RCS becomes evident through a systematic review. Methods: We conducted a search in PubMed, including cohort and case-control studies which assessed various categories of RCS exposure. A search was also conducted on the webpages of institutional organizations. A qualitative data synthesis was performed. Results: Twenty studies were included. Studies that assessed lung cancer mortality and incidence displayed wide variability both in RCS exposure categories and related risks. Although most studies found no significant association for RCS exposure categories, it appears to be a low risk of lung cancer for mean concentrations of less than 0.07mg/m3. Regulatory agencies set annual RCS exposure limits ranging from 0.025mg/m3 through 0.1mg/m3. Conclusions: There is a wide degree of heterogeneity in RCS exposure categories, with most studies observing no significant risk of lung cancer for the lowest exposure categories. Cut-off points differ between agencies but are nonetheless very similar and do not exceed 0.1mg/m3. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Occupational exposure to respirable crystalline silica and lung cancer: a systematic review of cut-off points.
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  Data: <searchLink fieldCode="AR" term="%22Rey-Brandariz%2C+Julia%22">Rey-Brandariz, Julia</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez%2C+Cristina%22">Martínez, Cristina</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Candal-Pedreira%2C+Cristina%22">Candal-Pedreira, Cristina</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pérez-Ríos%2C+Mónica%22">Pérez-Ríos, Mónica</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Varela-Lema%2C+Leonor%22">Varela-Lema, Leonor</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruano-Ravina%2C+Alberto%22">Ruano-Ravina, Alberto</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<i> alberto.ruano@usc.es</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 11/30/2023, Vol. 22 Issue 1, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Occupational+exposure%22">Occupational exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+cancer%22">Lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Silica%22">Silica</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer-related+mortality%22">Cancer-related mortality</searchLink>
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  Data: Background: Respirable crystalline silica (RCS) is associated with the development of lung cancer. However, there is uncertainty around the exposure threshold at which exposure to RCS may pose a clear risk for the development of lung cancer. The objective of this study was to review the cut-off points at which the risk of mortality or incidence of lung cancer due to occupational exposure to RCS becomes evident through a systematic review. Methods: We conducted a search in PubMed, including cohort and case-control studies which assessed various categories of RCS exposure. A search was also conducted on the webpages of institutional organizations. A qualitative data synthesis was performed. Results: Twenty studies were included. Studies that assessed lung cancer mortality and incidence displayed wide variability both in RCS exposure categories and related risks. Although most studies found no significant association for RCS exposure categories, it appears to be a low risk of lung cancer for mean concentrations of less than 0.07mg/m3. Regulatory agencies set annual RCS exposure limits ranging from 0.025mg/m3 through 0.1mg/m3. Conclusions: There is a wide degree of heterogeneity in RCS exposure categories, with most studies observing no significant risk of lung cancer for the lowest exposure categories. Cut-off points differ between agencies but are nonetheless very similar and do not exceed 0.1mg/m3. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 11/30/2023
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