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Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project.

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Title: Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project.
Authors: Chandna, Arjun1,2 arjun@tropmedres.ac, Rusheng Chew1,3,4, Nan Shwe Nwe Htun3, Peto, Thomas J.1,3, Meiwen Zhang1,3, Liverani, Marco5,6,7, Brummaier, Tobias1,8,9,10, Phommasone, Koukeo11, Perrone, Carlo3, Aung Pyae Phyo8, Sattabongkot, Jetsumon12,13, Roobsoong, Wanlapa12,13, Nguitragool, Wang14, Sen, Aninda15, Zaman, Sazid Ibna1,3, Zaw, Aye Sandar16, Batty, Elizabeth1,3, Waithira, Naomi1,3, Abdad, Mohammad Yazid1,3, Blacksell, Stuart D.1,3
Source: Wellcome Open Research. 2022, Vol. 7, p1-25. 25p.
Subject Terms: Fever, Mortality, Community health workers, Malaria treatment
Geographic Terms: Southeast Asia
Abstract: In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provide early diagnosis and treatment of malaria. However, for the majority of febrile patients, VHWs lack the training, support and resources to provide further care. Consequently, treatable bacterial illnesses are missed, antibiotics are overused and poorly targeted, and patient attendance wanes along with declining malaria. This Open Letter announces the start of a new initiative, the Rural Febrile Illness (RFI) project, the first in a series of projects to be implemented as part of the South and Southeast Asian Communitybased Trials Network (SEACTN) research programme. This multicountry, multi-site project will run in Bangladesh, Cambodia, Lao PDR, Thailand, and Myanmar. It will define the epidemiological baseline of febrile illness in nine remote and underserved areas of Asia where malaria endemicity is declining and access to health services is limited. The RFI project aims to determine the incidence, causes and outcomes of febrile illness; understand the opportunities, barriers and appetite for adjustment of the role of VHWs to include management of nonmalarial febrile illnesses; and establish a network of community healthcare providers and facilities capable of implementing interventions designed to triage, diagnose and treat patients presenting with febrile illnesses within these communities in the future. [ABSTRACT FROM AUTHOR]
Copyright of Wellcome Open Research is the property of Wellcome Trust and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project.
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  Data: <searchLink fieldCode="AR" term="%22Chandna%2C+Arjun%22">Chandna, Arjun</searchLink><relatesTo>1,2</relatesTo><i> arjun@tropmedres.ac</i><br /><searchLink fieldCode="AR" term="%22Rusheng+Chew%22">Rusheng Chew</searchLink><relatesTo>1,3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Nan+Shwe+Nwe+Htun%22">Nan Shwe Nwe Htun</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Peto%2C+Thomas+J%2E%22">Peto, Thomas J.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Meiwen+Zhang%22">Meiwen Zhang</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Liverani%2C+Marco%22">Liverani, Marco</searchLink><relatesTo>5,6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Brummaier%2C+Tobias%22">Brummaier, Tobias</searchLink><relatesTo>1,8,9,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Phommasone%2C+Koukeo%22">Phommasone, Koukeo</searchLink><relatesTo>11</relatesTo><br /><searchLink fieldCode="AR" term="%22Perrone%2C+Carlo%22">Perrone, Carlo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Aung+Pyae+Phyo%22">Aung Pyae Phyo</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Sattabongkot%2C+Jetsumon%22">Sattabongkot, Jetsumon</searchLink><relatesTo>12,13</relatesTo><br /><searchLink fieldCode="AR" term="%22Roobsoong%2C+Wanlapa%22">Roobsoong, Wanlapa</searchLink><relatesTo>12,13</relatesTo><br /><searchLink fieldCode="AR" term="%22Nguitragool%2C+Wang%22">Nguitragool, Wang</searchLink><relatesTo>14</relatesTo><br /><searchLink fieldCode="AR" term="%22Sen%2C+Aninda%22">Sen, Aninda</searchLink><relatesTo>15</relatesTo><br /><searchLink fieldCode="AR" term="%22Zaman%2C+Sazid+Ibna%22">Zaman, Sazid Ibna</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zaw%2C+Aye+Sandar%22">Zaw, Aye Sandar</searchLink><relatesTo>16</relatesTo><br /><searchLink fieldCode="AR" term="%22Batty%2C+Elizabeth%22">Batty, Elizabeth</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Waithira%2C+Naomi%22">Waithira, Naomi</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Abdad%2C+Mohammad+Yazid%22">Abdad, Mohammad Yazid</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Blacksell%2C+Stuart+D%2E%22">Blacksell, Stuart D.</searchLink><relatesTo>1,3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Wellcome+Open+Research%22">Wellcome Open Research</searchLink>. 2022, Vol. 7, p1-25. 25p.
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  Data: <searchLink fieldCode="DE" term="%22Fever%22">Fever</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality%22">Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Community+health+workers%22">Community health workers</searchLink><br /><searchLink fieldCode="DE" term="%22Malaria+treatment%22">Malaria treatment</searchLink>
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  Data: In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provide early diagnosis and treatment of malaria. However, for the majority of febrile patients, VHWs lack the training, support and resources to provide further care. Consequently, treatable bacterial illnesses are missed, antibiotics are overused and poorly targeted, and patient attendance wanes along with declining malaria. This Open Letter announces the start of a new initiative, the Rural Febrile Illness (RFI) project, the first in a series of projects to be implemented as part of the South and Southeast Asian Communitybased Trials Network (SEACTN) research programme. This multicountry, multi-site project will run in Bangladesh, Cambodia, Lao PDR, Thailand, and Myanmar. It will define the epidemiological baseline of febrile illness in nine remote and underserved areas of Asia where malaria endemicity is declining and access to health services is limited. The RFI project aims to determine the incidence, causes and outcomes of febrile illness; understand the opportunities, barriers and appetite for adjustment of the role of VHWs to include management of nonmalarial febrile illnesses; and establish a network of community healthcare providers and facilities capable of implementing interventions designed to triage, diagnose and treat patients presenting with febrile illnesses within these communities in the future. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Wellcome Open Research is the property of Wellcome Trust and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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