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Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.

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Title: Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.
Authors: Mingyu Zhang1,2 mzhang16@bidmc.harvard.edu, Rifas-Shiman, Sheryl L.1, Aris, Izzuddin M.1, Fleisch, Abby F.3,4, Lin, Pi-I Debby1, Nichols, Amy R.1,5, Oken, Emily1,5, Hivert, Marie-France1,6
Source: Environmental Health Perspectives. Dec2023, Vol. 131 Issue 12, p127002-1-127002-15. 15p.
Subject Terms: *Pollutants, *Photon absorptiometry, *Fluorocarbons, *Environmental health, Obesity risk factors, Maternal exposure, Body composition, Statistics, Confidence intervals, Skinfold thickness, Multivariate analysis, Regression analysis, Prenatal exposure delayed effects, Risk assessment, Waist-hip ratio, Sex distribution, Research funding, Descriptive statistics, Body mass index, Data analysis, Data analysis software, Adipose tissues, Longitudinal method, Poisson distribution, Adults, Adolescence
Geographic Terms: Massachusetts
Abstract: BACKGROUND: Findings on the associations between prenatal PFAS exposures and offspring adiposity are inconsistent. Whether such associations may extend to adolescence is especially understudied. OBJECTIVES: We investigated associations of prenatal PFAS exposures with offspring adiposity and body composition at 16-20 years of age. METHODS: We studied 545 mother-child pairs in the prospective prebirth cohort Project Viva (Boston, Massachusetts). We measured six PFAS (PFOA, PFOS, PFNA, PFHxS, EtFOSAA, and MeFOSAA) in maternal early pregnancy (median age = 9.6 wk, range: 5.7-19.6 wk) plasma samples. At the late adolescence visit (median age = 17.4 y, range: 15.9-20.0 y), we obtained anthropometric measures and assessed body composition using bioelectrical impedance analysis and dual-energy X-ray absorptiometry. We examined associations of individual PFAS with obesity [i.e., age- and sex-specific body mass index (BMI) = 95th percentile] and adiposity and body composition using multivariable Poisson and linear regression models, respectively. We assessed PFAS mixture effects using Bayesian kernel machine regression (BKMR) and quantile g-computation. We used fractional- polynomial models to assess BMI trajectories (at 3-20 years of age) by prenatal PFAS levels. RESULTS: Thirteen percent (n=73) of the children had obesity in late adolescence. After multivariable adjustment, higher prenatal PFAS concentra- tions were associated with higher obesity risk [e.g., 1.59 (95% CI: 1.19, 2.12), 1.24 (95% CI: 0.98, 1.57), and 1.49 (95% CI: 1.11, 1.99) times the obe- sity risk per doubling of PFOS, PFOA, and PFNA, respectively]. BKMR showed an interaction between PFOA and PFOS, where the positive association between PFOS and obesity was stronger when PFOA levels were lower. Each quartile increment of the PFAS mixture was associated with 1.52 (95% CI: 1.03, 2.25) times the obesity risk and 0.52 (95% CI: -0.02, 1.06) kg/m² higher BMI. Children with higher prenatal PFOS, EtFOSAA, and MeFOSAA concentrations had higher rates of BMI increase starting from 9-11 years of age. DISCUSSION: Prenatal PFAS exposures may have obesogenic effects into late adolescence. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.
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  Data: <searchLink fieldCode="AR" term="%22Mingyu+Zhang%22">Mingyu Zhang</searchLink><relatesTo>1,2</relatesTo><i> mzhang16@bidmc.harvard.edu</i><br /><searchLink fieldCode="AR" term="%22Rifas-Shiman%2C+Sheryl+L%2E%22">Rifas-Shiman, Sheryl L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Aris%2C+Izzuddin+M%2E%22">Aris, Izzuddin M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fleisch%2C+Abby+F%2E%22">Fleisch, Abby F.</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Pi-I+Debby%22">Lin, Pi-I Debby</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nichols%2C+Amy+R%2E%22">Nichols, Amy R.</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Oken%2C+Emily%22">Oken, Emily</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Hivert%2C+Marie-France%22">Hivert, Marie-France</searchLink><relatesTo>1,6</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Dec2023, Vol. 131 Issue 12, p127002-1-127002-15. 15p.
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  Data: *<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Photon+absorptiometry%22">Photon absorptiometry</searchLink><br />*<searchLink fieldCode="DE" term="%22Fluorocarbons%22">Fluorocarbons</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+health%22">Environmental health</searchLink><br /><searchLink fieldCode="DE" term="%22Obesity+risk+factors%22">Obesity risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal+exposure%22">Maternal exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Body+composition%22">Body composition</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Skinfold+thickness%22">Skinfold thickness</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+exposure+delayed+effects%22">Prenatal exposure delayed effects</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Waist-hip+ratio%22">Waist-hip ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Adipose+tissues%22">Adipose tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Poisson+distribution%22">Poisson distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Massachusetts%22">Massachusetts</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: BACKGROUND: Findings on the associations between prenatal PFAS exposures and offspring adiposity are inconsistent. Whether such associations may extend to adolescence is especially understudied. OBJECTIVES: We investigated associations of prenatal PFAS exposures with offspring adiposity and body composition at 16-20 years of age. METHODS: We studied 545 mother-child pairs in the prospective prebirth cohort Project Viva (Boston, Massachusetts). We measured six PFAS (PFOA, PFOS, PFNA, PFHxS, EtFOSAA, and MeFOSAA) in maternal early pregnancy (median age = 9.6 wk, range: 5.7-19.6 wk) plasma samples. At the late adolescence visit (median age = 17.4 y, range: 15.9-20.0 y), we obtained anthropometric measures and assessed body composition using bioelectrical impedance analysis and dual-energy X-ray absorptiometry. We examined associations of individual PFAS with obesity [i.e., age- and sex-specific body mass index (BMI) = 95th percentile] and adiposity and body composition using multivariable Poisson and linear regression models, respectively. We assessed PFAS mixture effects using Bayesian kernel machine regression (BKMR) and quantile g-computation. We used fractional- polynomial models to assess BMI trajectories (at 3-20 years of age) by prenatal PFAS levels. RESULTS: Thirteen percent (n=73) of the children had obesity in late adolescence. After multivariable adjustment, higher prenatal PFAS concentra- tions were associated with higher obesity risk [e.g., 1.59 (95% CI: 1.19, 2.12), 1.24 (95% CI: 0.98, 1.57), and 1.49 (95% CI: 1.11, 1.99) times the obe- sity risk per doubling of PFOS, PFOA, and PFNA, respectively]. BKMR showed an interaction between PFOA and PFOS, where the positive association between PFOS and obesity was stronger when PFOA levels were lower. Each quartile increment of the PFAS mixture was associated with 1.52 (95% CI: 1.03, 2.25) times the obesity risk and 0.52 (95% CI: -0.02, 1.06) kg/m² higher BMI. Children with higher prenatal PFOS, EtFOSAA, and MeFOSAA concentrations had higher rates of BMI increase starting from 9-11 years of age. DISCUSSION: Prenatal PFAS exposures may have obesogenic effects into late adolescence. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/EHP12597
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 127002-1
    Subjects:
      – SubjectFull: Pollutants
        Type: general
      – SubjectFull: Photon absorptiometry
        Type: general
      – SubjectFull: Fluorocarbons
        Type: general
      – SubjectFull: Environmental health
        Type: general
      – SubjectFull: Obesity risk factors
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      – SubjectFull: Maternal exposure
        Type: general
      – SubjectFull: Body composition
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      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Skinfold thickness
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Prenatal exposure delayed effects
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Waist-hip ratio
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Body mass index
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      – SubjectFull: Data analysis
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      – SubjectFull: Data analysis software
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      – SubjectFull: Adipose tissues
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Poisson distribution
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      – SubjectFull: Adults
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      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Massachusetts
        Type: general
    Titles:
      – TitleFull: Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.
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              Text: Dec2023
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