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Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota.

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Title: Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota.
Authors: Jeong, Bohyeon1 (AUTHOR), Kim, Ji-Sun2 (AUTHOR), Kwon, A Ra3 (AUTHOR), Lee, Jangjae3,4 (AUTHOR), Park, Subin1 (AUTHOR), Koo, Jahong1,5 (AUTHOR), Lee, Wang Sik6 (AUTHOR), Baek, Jeong Yeob1 (AUTHOR), Shin, Won-Ho7 (AUTHOR), Lee, Jung-Sook2,5 (AUTHOR), Jeong, Jinyoung5,6 (AUTHOR), Kim, Won Kon5,8 (AUTHOR), Jung, Cho-Rok5,9 (AUTHOR), Kim, Nam-Soon1,5 (AUTHOR), Cho, Sung-Hee1,3 (AUTHOR) shc0429@krict.re.kr, Lee, Da Yong1,5 (AUTHOR) daylee@kribb.re.kr
Source: Environment International. Mar2024, Vol. 185, pN.PAG-N.PAG. 1p.
Subject Terms: Body weight, Body composition, Composition of breast milk, Weight gain, Childhood obesity, Fat
Abstract: [Display omitted] • Maternal ingestion of NPs increase the body weight of progeny by the elevation of fat mass. • Maternal administration of NPs alters the lipid composition in breast milk and progeny plasma. • PLA2 inhibition restores the PS NP-induced changes in lipid composition and body weight. • PS NP induces obesity-like microbial distribution with no relation to the lipidomic changes. The rapidly increasing prevalence of obesity and overweight, especially in children and adolescents, has become a serious societal issue. Although various genetic and environmental risk factors for pediatric obesity and overweight have been identified, the problem has not been solved. In this study, we examined whether environmental nanoplastic (NP) pollutants can act as environmental obesogens using mouse models exposed to NPs derived from polystyrene and polypropylene, which are abundant in the environment. We found abnormal weight gain in the progeny until 6 weeks of age following the oral administration of NPs to the mother during gestation and lactation. Through a series of experiments involving multi-omic analyses, we have demonstrated that NP-induced weight gain is caused by alterations in the lipid composition (lysophosphatidylcholine/phosphatidylcholine ratio) of maternal breast milk and he gut microbiota distribution of the progeny. These data indicate that environmental NPs can act as obesogens in childhood. [ABSTRACT FROM AUTHOR]
Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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An: 176229227
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  Data: Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota.
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  Data: <searchLink fieldCode="AR" term="%22Jeong%2C+Bohyeon%22">Jeong, Bohyeon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Ji-Sun%22">Kim, Ji-Sun</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon%2C+A+Ra%22">Kwon, A Ra</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jangjae%22">Lee, Jangjae</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Subin%22">Park, Subin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koo%2C+Jahong%22">Koo, Jahong</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Wang+Sik%22">Lee, Wang Sik</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baek%2C+Jeong+Yeob%22">Baek, Jeong Yeob</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shin%2C+Won-Ho%22">Shin, Won-Ho</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jung-Sook%22">Lee, Jung-Sook</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeong%2C+Jinyoung%22">Jeong, Jinyoung</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Won+Kon%22">Kim, Won Kon</searchLink><relatesTo>5,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jung%2C+Cho-Rok%22">Jung, Cho-Rok</searchLink><relatesTo>5,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Nam-Soon%22">Kim, Nam-Soon</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cho%2C+Sung-Hee%22">Cho, Sung-Hee</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> shc0429@krict.re.kr</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Da+Yong%22">Lee, Da Yong</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> daylee@kribb.re.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Environment+International%22">Environment International</searchLink>. Mar2024, Vol. 185, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Body+weight%22">Body weight</searchLink><br /><searchLink fieldCode="DE" term="%22Body+composition%22">Body composition</searchLink><br /><searchLink fieldCode="DE" term="%22Composition+of+breast+milk%22">Composition of breast milk</searchLink><br /><searchLink fieldCode="DE" term="%22Weight+gain%22">Weight gain</searchLink><br /><searchLink fieldCode="DE" term="%22Childhood+obesity%22">Childhood obesity</searchLink><br /><searchLink fieldCode="DE" term="%22Fat%22">Fat</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: [Display omitted] • Maternal ingestion of NPs increase the body weight of progeny by the elevation of fat mass. • Maternal administration of NPs alters the lipid composition in breast milk and progeny plasma. • PLA2 inhibition restores the PS NP-induced changes in lipid composition and body weight. • PS NP induces obesity-like microbial distribution with no relation to the lipidomic changes. The rapidly increasing prevalence of obesity and overweight, especially in children and adolescents, has become a serious societal issue. Although various genetic and environmental risk factors for pediatric obesity and overweight have been identified, the problem has not been solved. In this study, we examined whether environmental nanoplastic (NP) pollutants can act as environmental obesogens using mouse models exposed to NPs derived from polystyrene and polypropylene, which are abundant in the environment. We found abnormal weight gain in the progeny until 6 weeks of age following the oral administration of NPs to the mother during gestation and lactation. Through a series of experiments involving multi-omic analyses, we have demonstrated that NP-induced weight gain is caused by alterations in the lipid composition (lysophosphatidylcholine/phosphatidylcholine ratio) of maternal breast milk and he gut microbiota distribution of the progeny. These data indicate that environmental NPs can act as obesogens in childhood. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.envint.2024.108522
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Body weight
        Type: general
      – SubjectFull: Body composition
        Type: general
      – SubjectFull: Composition of breast milk
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      – SubjectFull: Weight gain
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      – SubjectFull: Childhood obesity
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      – SubjectFull: Fat
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      – TitleFull: Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota.
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