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Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism.

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Title: Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism.
Authors: Gelu-Simeon, Moana1,2 (AUTHOR) moana.simeon@chu-guadeloupe.fr, Lafrance, Marie-Josée2 (AUTHOR), Michineau, Leah3 (AUTHOR), Saillard, Eric2 (AUTHOR), Thomé, Jean Pierre4 (AUTHOR), Emond, Claude5,6 (AUTHOR), Samson, Michel3 (AUTHOR) michel.samson@inserm.fr, Multigner, Luc3 (AUTHOR)
Source: Environmental Health: A Global Access Science Source. 3/20/2024, Vol. 23 Issue 1, p1-9. 9p.
Subject Terms: *Chlordecone, *Pollutants, *Persistent pollutants, Hepatic fibrosis, Chronic active hepatitis
Geographic Terms: West Indies
Abstract: Background and Aims: Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has been demonstrated in animal models. We investigated the relationship between environmental exposure to chlordecone and the progression of liver fibrosis. Methods: This study included 182 consecutive patients with chronic alcoholic hepatitis whose liver fibrosis was assessed using non-invasive methods. Measured plasma chlordecone concentrations at inclusion were used as surrogate of long-term exposure under steady-state conditions. As the pharmacokinetic processing of chlordecone is largely determined by the liver, we used a human physiologically based pharmacokinetic model to predict plausible changes in the steady-state blood chlordecone concentrations induced by liver fibrosis. Results: With a median follow-up of 27.1 years after the onset of alcohol consumption, we found a significant decrease in the risk of advanced liver fibrosis with increasing plasma chlordecone concentration (adjusted hazard ratio = 0.56; 95% confidence interval: 0.34–0.95 for the highest vs. lowest tertile, p = 0.04). Changes induced by liver fibrosis influenced the pharmacokinetic processing of chlordecone, resulting in substantial modifications in its steady-state blood concentrations. Conclusion: According to this human model of coexposure to alcohol, reverse causality is the most plausible explanation of this inverse association between plasma chlordecone concentrations and progression of liver fibrosis. This study underlines the importance of considering the pharmacokinetic of environmental contaminants in epidemiological studies when biomarkers of exposure are used to investigate their own impact on the liver. Trial registration: ClinicalTrials.gov Identifier: NCT03373396. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism.
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  Data: <searchLink fieldCode="AR" term="%22Gelu-Simeon%2C+Moana%22">Gelu-Simeon, Moana</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> moana.simeon@chu-guadeloupe.fr</i><br /><searchLink fieldCode="AR" term="%22Lafrance%2C+Marie-Josée%22">Lafrance, Marie-Josée</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michineau%2C+Leah%22">Michineau, Leah</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saillard%2C+Eric%22">Saillard, Eric</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomé%2C+Jean+Pierre%22">Thomé, Jean Pierre</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Emond%2C+Claude%22">Emond, Claude</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samson%2C+Michel%22">Samson, Michel</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> michel.samson@inserm.fr</i><br /><searchLink fieldCode="AR" term="%22Multigner%2C+Luc%22">Multigner, Luc</searchLink><relatesTo>3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 3/20/2024, Vol. 23 Issue 1, p1-9. 9p.
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  Data: *<searchLink fieldCode="DE" term="%22Chlordecone%22">Chlordecone</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Persistent+pollutants%22">Persistent pollutants</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+fibrosis%22">Hepatic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+active+hepatitis%22">Chronic active hepatitis</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22West+Indies%22">West Indies</searchLink>
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  Data: Background and Aims: Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has been demonstrated in animal models. We investigated the relationship between environmental exposure to chlordecone and the progression of liver fibrosis. Methods: This study included 182 consecutive patients with chronic alcoholic hepatitis whose liver fibrosis was assessed using non-invasive methods. Measured plasma chlordecone concentrations at inclusion were used as surrogate of long-term exposure under steady-state conditions. As the pharmacokinetic processing of chlordecone is largely determined by the liver, we used a human physiologically based pharmacokinetic model to predict plausible changes in the steady-state blood chlordecone concentrations induced by liver fibrosis. Results: With a median follow-up of 27.1 years after the onset of alcohol consumption, we found a significant decrease in the risk of advanced liver fibrosis with increasing plasma chlordecone concentration (adjusted hazard ratio = 0.56; 95% confidence interval: 0.34–0.95 for the highest vs. lowest tertile, p = 0.04). Changes induced by liver fibrosis influenced the pharmacokinetic processing of chlordecone, resulting in substantial modifications in its steady-state blood concentrations. Conclusion: According to this human model of coexposure to alcohol, reverse causality is the most plausible explanation of this inverse association between plasma chlordecone concentrations and progression of liver fibrosis. This study underlines the importance of considering the pharmacokinetic of environmental contaminants in epidemiological studies when biomarkers of exposure are used to investigate their own impact on the liver. Trial registration: ClinicalTrials.gov Identifier: NCT03373396. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1186/s12940-024-01054-6
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        Text: English
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      – SubjectFull: Persistent pollutants
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              Text: 3/20/2024
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