View in EDS HTML Full Text PDF Full Text

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.

Saved in:
Bibliographic Details
Title: Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.
Authors: McBride, Danielle E.1 dani.mcbride@uky.edu, Bhattacharya, Amit2, Sucharew, Heidi3, Brunst, Kelly J.2, Barnas, Mary4, Cox, Cyndy2, Altman, Lorenna2, Hilbert, Timothy J.2, Burkle, Jeff2,5, Westneat, Susan1, Martin, Kaitlin Vollet1, Parsons, Patrick J.6,7, Praamsma, Meredith L.6,7, Palmer, Christopher D.6,7, Kannan, Kurunthachalam6,7, Smith, Donald R.8, Wright, Robert9, Amarasiriwardena, Chitra9, Dietrich, Kim N.2, Cecil, Kim M.2,10
Source: Environmental Health Perspectives. May2024, Vol. 132 Issue 5, p057010-1-057010-18. 18p.
Subject Terms: *Manganese, *Environmental health, *Environmental exposure, *Pollutants, *Lead, *Biomarkers, Cotinine, Pearson correlation (Statistics), Parents, Blood chemical analysis, Hair analysis, Liquid chromatography-mass spectrometry, Research funding, Multiple regression analysis, Sex distribution, Body weight, Nails (Anatomy), Descriptive statistics, Age distribution, Longitudinal method, Psychology of movement, Caregivers, Stature, Comparative studies, Data analysis software, Confidence intervals, Intelligence tests, Postural balance, Social classes, Adolescence, Children
Geographic Terms: Georgia
Abstract: BACKGROUND: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance OBJECTIVES: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. METHODS: Participants were recruited into CARES when they were 7–9 y old, and reenrolled at 13–18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height–weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. RESULTS: CARES participants who completed the adolescent postural balance assessment (푛 = 123) were 98% White and 54% female and had a mean age of 16 y (range: 13–18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males DISCUSSION: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: 8gh
DbLabel: GreenFILE
An: 177886312
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22McBride%2C+Danielle+E%2E%22">McBride, Danielle E.</searchLink><relatesTo>1</relatesTo><i> dani.mcbride@uky.edu</i><br /><searchLink fieldCode="AR" term="%22Bhattacharya%2C+Amit%22">Bhattacharya, Amit</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sucharew%2C+Heidi%22">Sucharew, Heidi</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Brunst%2C+Kelly+J%2E%22">Brunst, Kelly J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Barnas%2C+Mary%22">Barnas, Mary</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cox%2C+Cyndy%22">Cox, Cyndy</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Altman%2C+Lorenna%22">Altman, Lorenna</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hilbert%2C+Timothy+J%2E%22">Hilbert, Timothy J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Burkle%2C+Jeff%22">Burkle, Jeff</searchLink><relatesTo>2,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Westneat%2C+Susan%22">Westneat, Susan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Martin%2C+Kaitlin+Vollet%22">Martin, Kaitlin Vollet</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Parsons%2C+Patrick+J%2E%22">Parsons, Patrick J.</searchLink><relatesTo>6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Praamsma%2C+Meredith+L%2E%22">Praamsma, Meredith L.</searchLink><relatesTo>6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Palmer%2C+Christopher+D%2E%22">Palmer, Christopher D.</searchLink><relatesTo>6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Kannan%2C+Kurunthachalam%22">Kannan, Kurunthachalam</searchLink><relatesTo>6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Smith%2C+Donald+R%2E%22">Smith, Donald R.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Wright%2C+Robert%22">Wright, Robert</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Amarasiriwardena%2C+Chitra%22">Amarasiriwardena, Chitra</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Dietrich%2C+Kim+N%2E%22">Dietrich, Kim N.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cecil%2C+Kim+M%2E%22">Cecil, Kim M.</searchLink><relatesTo>2,10</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. May2024, Vol. 132 Issue 5, p057010-1-057010-18. 18p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Manganese%22">Manganese</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+health%22">Environmental health</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Lead%22">Lead</searchLink><br />*<searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Cotinine%22">Cotinine</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Parents%22">Parents</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+chemical+analysis%22">Blood chemical analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Hair+analysis%22">Hair analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Body+weight%22">Body weight</searchLink><br /><searchLink fieldCode="DE" term="%22Nails+%28Anatomy%29%22">Nails (Anatomy)</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+movement%22">Psychology of movement</searchLink><br /><searchLink fieldCode="DE" term="%22Caregivers%22">Caregivers</searchLink><br /><searchLink fieldCode="DE" term="%22Stature%22">Stature</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+tests%22">Intelligence tests</searchLink><br /><searchLink fieldCode="DE" term="%22Postural+balance%22">Postural balance</searchLink><br /><searchLink fieldCode="DE" term="%22Social+classes%22">Social classes</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Georgia%22">Georgia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance OBJECTIVES: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. METHODS: Participants were recruited into CARES when they were 7–9 y old, and reenrolled at 13–18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height–weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. RESULTS: CARES participants who completed the adolescent postural balance assessment (푛 = 123) were 98% White and 54% female and had a mean age of 16 y (range: 13–18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males DISCUSSION: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=177886312
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/EHP13381
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 057010-1
    Subjects:
      – SubjectFull: Manganese
        Type: general
      – SubjectFull: Environmental health
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Pollutants
        Type: general
      – SubjectFull: Lead
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Cotinine
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Parents
        Type: general
      – SubjectFull: Blood chemical analysis
        Type: general
      – SubjectFull: Hair analysis
        Type: general
      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Body weight
        Type: general
      – SubjectFull: Nails (Anatomy)
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Psychology of movement
        Type: general
      – SubjectFull: Caregivers
        Type: general
      – SubjectFull: Stature
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Intelligence tests
        Type: general
      – SubjectFull: Postural balance
        Type: general
      – SubjectFull: Social classes
        Type: general
      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Georgia
        Type: general
    Titles:
      – TitleFull: Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: McBride, Danielle E.
      – PersonEntity:
          Name:
            NameFull: Bhattacharya, Amit
      – PersonEntity:
          Name:
            NameFull: Sucharew, Heidi
      – PersonEntity:
          Name:
            NameFull: Brunst, Kelly J.
      – PersonEntity:
          Name:
            NameFull: Barnas, Mary
      – PersonEntity:
          Name:
            NameFull: Cox, Cyndy
      – PersonEntity:
          Name:
            NameFull: Altman, Lorenna
      – PersonEntity:
          Name:
            NameFull: Hilbert, Timothy J.
      – PersonEntity:
          Name:
            NameFull: Burkle, Jeff
      – PersonEntity:
          Name:
            NameFull: Westneat, Susan
      – PersonEntity:
          Name:
            NameFull: Martin, Kaitlin Vollet
      – PersonEntity:
          Name:
            NameFull: Parsons, Patrick J.
      – PersonEntity:
          Name:
            NameFull: Praamsma, Meredith L.
      – PersonEntity:
          Name:
            NameFull: Palmer, Christopher D.
      – PersonEntity:
          Name:
            NameFull: Kannan, Kurunthachalam
      – PersonEntity:
          Name:
            NameFull: Smith, Donald R.
      – PersonEntity:
          Name:
            NameFull: Wright, Robert
      – PersonEntity:
          Name:
            NameFull: Amarasiriwardena, Chitra
      – PersonEntity:
          Name:
            NameFull: Dietrich, Kim N.
      – PersonEntity:
          Name:
            NameFull: Cecil, Kim M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 132
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1