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An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia.

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Title: An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia.
Authors: Kumari, Ruchika1 (AUTHOR), Thakur, Ankita1 (AUTHOR), Thakur, Palak1 (AUTHOR), Sharma, Vipasha1 (AUTHOR), Sharma, Rohit2 (AUTHOR), Upmanyu, Sachin1 (AUTHOR), Singh, Randeep3 (AUTHOR), Almarhoon, Zainab M.4 (AUTHOR), Calina, Daniela5 (AUTHOR) calinadaniela@gmail.com, Sharifi‐Rad, Javad6,7,8 (AUTHOR) javad.sharifirad@gmail.com, Chaudhary, Ashun1 (AUTHOR) ashun.chaudhary@gmail.com
Source: Food Science & Nutrition. May2025, Vol. 13 Issue 5, p1-18. 18p.
Subject Terms: *Bioavailability, Cancer cell proliferation, Insulin sensitivity, Yams, History of medicine, Blood sugar
Abstract: Dioscorea oppositifolia L., also known as Cinnamon vine, has a longstanding history in traditional medicine due to its diverse bioactive compounds. However, comprehensive scientific evaluations of its phytochemical properties and therapeutic potential are still limited. This study provides an updated analysis of its nutritional composition, bioactive compounds, and pharmacological properties, emphasizing potential therapeutic applications. A comprehensive literature review was conducted using Google Scholar, Science Direct, and PubMed/MedLine, covering studies published between 2022 and 2023. Key bioactive constituents such as diosgenin and dioscorine were identified and evaluated for their biological activities, including antioxidant, anti‐inflammatory, antidiabetic, anticancer, and antimicrobial effects. The plant exhibits notable antioxidant activity by reducing oxidative stress, while its anti‐inflammatory effects are linked to cytokine inhibition. Antidiabetic properties are evidenced by blood glucose modulation and improved insulin sensitivity. Anticancer effects include apoptosis induction and suppression of cancer cell proliferation. Additionally, Dioscorea oppositifolia shows antimicrobial efficacy against various bacterial and fungal strains. Due to its broad‐spectrum bioactivities and rich phytochemical profile, Dioscorea oppositifolia emerges as a promising candidate for pharmaceutical applications. However, further research, including clinical trials and bioavailability studies, is essential to fully harness its therapeutic potential and facilitate its integration into modern medicine. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia.
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  Data: <searchLink fieldCode="AR" term="%22Kumari%2C+Ruchika%22">Kumari, Ruchika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thakur%2C+Ankita%22">Thakur, Ankita</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thakur%2C+Palak%22">Thakur, Palak</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharma%2C+Vipasha%22">Sharma, Vipasha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharma%2C+Rohit%22">Sharma, Rohit</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Upmanyu%2C+Sachin%22">Upmanyu, Sachin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Randeep%22">Singh, Randeep</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almarhoon%2C+Zainab+M%2E%22">Almarhoon, Zainab M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calina%2C+Daniela%22">Calina, Daniela</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> calinadaniela@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Sharifi‐Rad%2C+Javad%22">Sharifi‐Rad, Javad</searchLink><relatesTo>6,7,8</relatesTo> (AUTHOR)<i> javad.sharifirad@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Chaudhary%2C+Ashun%22">Chaudhary, Ashun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ashun.chaudhary@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. May2025, Vol. 13 Issue 5, p1-18. 18p.
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  Data: *<searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cell+proliferation%22">Cancer cell proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+sensitivity%22">Insulin sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Yams%22">Yams</searchLink><br /><searchLink fieldCode="DE" term="%22History+of+medicine%22">History of medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar%22">Blood sugar</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Dioscorea oppositifolia L., also known as Cinnamon vine, has a longstanding history in traditional medicine due to its diverse bioactive compounds. However, comprehensive scientific evaluations of its phytochemical properties and therapeutic potential are still limited. This study provides an updated analysis of its nutritional composition, bioactive compounds, and pharmacological properties, emphasizing potential therapeutic applications. A comprehensive literature review was conducted using Google Scholar, Science Direct, and PubMed/MedLine, covering studies published between 2022 and 2023. Key bioactive constituents such as diosgenin and dioscorine were identified and evaluated for their biological activities, including antioxidant, anti‐inflammatory, antidiabetic, anticancer, and antimicrobial effects. The plant exhibits notable antioxidant activity by reducing oxidative stress, while its anti‐inflammatory effects are linked to cytokine inhibition. Antidiabetic properties are evidenced by blood glucose modulation and improved insulin sensitivity. Anticancer effects include apoptosis induction and suppression of cancer cell proliferation. Additionally, Dioscorea oppositifolia shows antimicrobial efficacy against various bacterial and fungal strains. Due to its broad‐spectrum bioactivities and rich phytochemical profile, Dioscorea oppositifolia emerges as a promising candidate for pharmaceutical applications. However, further research, including clinical trials and bioavailability studies, is essential to fully harness its therapeutic potential and facilitate its integration into modern medicine. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/fsn3.70179
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        Text: English
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      – SubjectFull: Bioavailability
        Type: general
      – SubjectFull: Cancer cell proliferation
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      – SubjectFull: Insulin sensitivity
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      – SubjectFull: Blood sugar
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              Text: May2025
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