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Obesity as a mediator in the association between urinary polycyclic aromatic hydrocarbon exposure and liver fibrosis risk in US adults.

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Title: Obesity as a mediator in the association between urinary polycyclic aromatic hydrocarbon exposure and liver fibrosis risk in US adults.
Authors: Guo, Wang1 (AUTHOR), Ye, Beizhu2 (AUTHOR), Ma, Xiaoli1 (AUTHOR), Liu, Jinying1 (AUTHOR), Yue, Yanqin1 (AUTHOR), Yang, Xingyuan1 (AUTHOR), Hou, Jian3 (AUTHOR) houjian1988@zzu.edu.cn, Li, Xiuling1 (AUTHOR) lixiuling@zzu.edu.cn, Luo, Xiaoying1 (AUTHOR) lxycs2015@zzu.edu.cn
Source: Environmental Science: Processes & Impacts. Jul2025, Vol. 27 Issue 7, p2082-2093. 12p.
Subject Terms: *Polycyclic aromatic hydrocarbons, *Health risk assessment, Obesity, Mediation (Statistics), Logistic regression analysis, National Health & Nutrition Examination Survey, Hepatic fibrosis
Geographic Terms: United States
Abstract: Polycyclic aromatic hydrocarbon (PAH) exposure may be associated with obesity-mediated liver injury. However, there is a lack of evidence on the role of obesity in associations of PAH exposure with liver fibrosis among population-based studies. Participant data were sourced from the National Health and Nutrition Survey 2001–2016. Urinary metabolites of PAHs were analyzed using gas chromatography-mass spectrometry. Liver fibrosis was classified as low and high risk. The weight-adjusted waist index (WWI) was calculated by waist circumference divided by the square of the weight. Logistic regression models and WQS regression were used to explore associations between exposure to six types of PAHs and the risk of liver fibrosis in adults and the mediating effects of obesity on the above-mentioned associations were further analyzed. Multiple urinary PAH metabolites were associated with increased risk of liver fibrosis. Positive association between a mixture of 6 PAHs and liver fibrosis (OR: 1.41, 95% CI: 1.10–1.80) was found and 2-naphthol, 1-pyrene, 1-naphthol, and 2-fluorene were the primary contributors to this association. Furthermore, the proportion mediation of obesity on associations of individual and the mixture of PAHs with liver fibrosis ranged from 4.6% to 38.3%. The results of this study showed that exposure to the mixture of PAHs was associated with increased liver fibrosis and these associations were partially mediated by obesity. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Science: Processes & Impacts is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Obesity as a mediator in the association between urinary polycyclic aromatic hydrocarbon exposure and liver fibrosis risk in US adults.
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  Data: <searchLink fieldCode="AR" term="%22Guo%2C+Wang%22">Guo, Wang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Beizhu%22">Ye, Beizhu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Xiaoli%22">Ma, Xiaoli</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jinying%22">Liu, Jinying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yue%2C+Yanqin%22">Yue, Yanqin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xingyuan%22">Yang, Xingyuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hou%2C+Jian%22">Hou, Jian</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> houjian1988@zzu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Xiuling%22">Li, Xiuling</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lixiuling@zzu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Luo%2C+Xiaoying%22">Luo, Xiaoying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lxycs2015@zzu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Science%3A+Processes+%26+Impacts%22">Environmental Science: Processes & Impacts</searchLink>. Jul2025, Vol. 27 Issue 7, p2082-2093. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22Polycyclic+aromatic+hydrocarbons%22">Polycyclic aromatic hydrocarbons</searchLink><br />*<searchLink fieldCode="DE" term="%22Health+risk+assessment%22">Health risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Obesity%22">Obesity</searchLink><br /><searchLink fieldCode="DE" term="%22Mediation+%28Statistics%29%22">Mediation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22National+Health+%26+Nutrition+Examination+Survey%22">National Health & Nutrition Examination Survey</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+fibrosis%22">Hepatic fibrosis</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Polycyclic aromatic hydrocarbon (PAH) exposure may be associated with obesity-mediated liver injury. However, there is a lack of evidence on the role of obesity in associations of PAH exposure with liver fibrosis among population-based studies. Participant data were sourced from the National Health and Nutrition Survey 2001–2016. Urinary metabolites of PAHs were analyzed using gas chromatography-mass spectrometry. Liver fibrosis was classified as low and high risk. The weight-adjusted waist index (WWI) was calculated by waist circumference divided by the square of the weight. Logistic regression models and WQS regression were used to explore associations between exposure to six types of PAHs and the risk of liver fibrosis in adults and the mediating effects of obesity on the above-mentioned associations were further analyzed. Multiple urinary PAH metabolites were associated with increased risk of liver fibrosis. Positive association between a mixture of 6 PAHs and liver fibrosis (OR: 1.41, 95% CI: 1.10–1.80) was found and 2-naphthol, 1-pyrene, 1-naphthol, and 2-fluorene were the primary contributors to this association. Furthermore, the proportion mediation of obesity on associations of individual and the mixture of PAHs with liver fibrosis ranged from 4.6% to 38.3%. The results of this study showed that exposure to the mixture of PAHs was associated with increased liver fibrosis and these associations were partially mediated by obesity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Science: Processes & Impacts is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1039/d5em00050e
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 2082
    Subjects:
      – SubjectFull: Polycyclic aromatic hydrocarbons
        Type: general
      – SubjectFull: Health risk assessment
        Type: general
      – SubjectFull: Obesity
        Type: general
      – SubjectFull: Mediation (Statistics)
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: National Health & Nutrition Examination Survey
        Type: general
      – SubjectFull: Hepatic fibrosis
        Type: general
      – SubjectFull: United States
        Type: general
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      – TitleFull: Obesity as a mediator in the association between urinary polycyclic aromatic hydrocarbon exposure and liver fibrosis risk in US adults.
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            – D: 01
              M: 07
              Text: Jul2025
              Type: published
              Y: 2025
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