GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals.
Saved in:
| Title: | GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals. |
|---|---|
| Authors: | Aati, Hanan Y.1 (AUTHOR) hati@ksu.edu.sa, Al‐Arifi, Renad2 (AUTHOR), Ovatlarnporn, Chitchamai3,4 (AUTHOR), AlYami, Khloud1 (AUTHOR) Kyami@ksu.edu.sa, Rauf, Abdul3,4 (AUTHOR), Basit, Abdul3,4 (AUTHOR), Rao, Huma5 (AUTHOR) Huma.rao@uhs.edu.pk, Batool, Maria6 (AUTHOR), Khan, Kashif ur Rehman6 (AUTHOR) kashifur.rahman@iub.edu.pk |
| Source: | Food Science & Nutrition. Sep2025, Vol. 13 Issue 9, p1-15. 15p. |
| Subject Terms: | *Gas chromatography/Mass spectrometry (GC-MS), Phytochemicals, Therapeutics, Antioxidants, Annona, Functional foods, Saudi Arabians |
| Geographic Terms: | Saudi Arabia |
| Abstract: | Annona squamosa L., commonly known as sugar apple or custard apple, is a well‐known medicinal plant recently introduced for cultivation in Saudi Arabia. However, the pharmaceutical potential of the Saudi cultivar remains unexplored. This study aimed to evaluate the phytochemical composition and biological activities of the ethanolic extract of Saudi A. squamosa fruit (EASF) through comprehensive in vitro and in silico analyses. Phytochemical screening revealed a high content of phenolics, flavonoids, and tannins.GC‐MS analysis identified 34 bioactive compounds, including fatty acid esters and terpenoids. EASF exhibited strong anti‐oxidant activity, particularly in the ABTS assay, and demonstrated significant thrombolytic potential (90.21% ± 0.90%) along with moderate hemolytic activity (14.1% ± 1.01%). Notably, the extract showed effective antibacterial activity against Staphylococcus epidermidis with an inhibition zone of 11 mm at 150 mg/mL. Enzyme inhibition assays revealed potent activity against urease (95.65%), tyrosinase (85.50%), and α‐amylase (47.88%). In silico molecular docking supported these findings, with selected phytoconstituents showing strong binding affinities toward the target enzymes. ADMET profiling further confirmed their drug‐like properties. These results suggest that the Saudi cultivar of A. squamosa possesses significant therapeutic potential and may serve as a promising candidate for developing nutraceuticals and pharmaceutical agents. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: 8gh DbLabel: GreenFILE An: 188235098 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aati%2C+Hanan+Y%2E%22">Aati, Hanan Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hati@ksu.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Al‐Arifi%2C+Renad%22">Al‐Arifi, Renad</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ovatlarnporn%2C+Chitchamai%22">Ovatlarnporn, Chitchamai</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22AlYami%2C+Khloud%22">AlYami, Khloud</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Kyami@ksu.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Rauf%2C+Abdul%22">Rauf, Abdul</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basit%2C+Abdul%22">Basit, Abdul</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rao%2C+Huma%22">Rao, Huma</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> Huma.rao@uhs.edu.pk</i><br /><searchLink fieldCode="AR" term="%22Batool%2C+Maria%22">Batool, Maria</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Kashif+ur+Rehman%22">Khan, Kashif ur Rehman</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> kashifur.rahman@iub.edu.pk</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Sep2025, Vol. 13 Issue 9, p1-15. 15p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Gas+chromatography%2FMass+spectrometry+%28GC-MS%29%22">Gas chromatography/Mass spectrometry (GC-MS)</searchLink><br /><searchLink fieldCode="DE" term="%22Phytochemicals%22">Phytochemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Annona%22">Annona</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+foods%22">Functional foods</searchLink><br /><searchLink fieldCode="DE" term="%22Saudi+Arabians%22">Saudi Arabians</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Saudi+Arabia%22">Saudi Arabia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Annona squamosa L., commonly known as sugar apple or custard apple, is a well‐known medicinal plant recently introduced for cultivation in Saudi Arabia. However, the pharmaceutical potential of the Saudi cultivar remains unexplored. This study aimed to evaluate the phytochemical composition and biological activities of the ethanolic extract of Saudi A. squamosa fruit (EASF) through comprehensive in vitro and in silico analyses. Phytochemical screening revealed a high content of phenolics, flavonoids, and tannins.GC‐MS analysis identified 34 bioactive compounds, including fatty acid esters and terpenoids. EASF exhibited strong anti‐oxidant activity, particularly in the ABTS assay, and demonstrated significant thrombolytic potential (90.21% ± 0.90%) along with moderate hemolytic activity (14.1% ± 1.01%). Notably, the extract showed effective antibacterial activity against Staphylococcus epidermidis with an inhibition zone of 11 mm at 150 mg/mL. Enzyme inhibition assays revealed potent activity against urease (95.65%), tyrosinase (85.50%), and α‐amylase (47.88%). In silico molecular docking supported these findings, with selected phytoconstituents showing strong binding affinities toward the target enzymes. ADMET profiling further confirmed their drug‐like properties. These results suggest that the Saudi cultivar of A. squamosa possesses significant therapeutic potential and may serve as a promising candidate for developing nutraceuticals and pharmaceutical agents. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=188235098 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/fsn3.70723 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1 Subjects: – SubjectFull: Gas chromatography/Mass spectrometry (GC-MS) Type: general – SubjectFull: Phytochemicals Type: general – SubjectFull: Therapeutics Type: general – SubjectFull: Antioxidants Type: general – SubjectFull: Annona Type: general – SubjectFull: Functional foods Type: general – SubjectFull: Saudi Arabians Type: general – SubjectFull: Saudi Arabia Type: general Titles: – TitleFull: GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aati, Hanan Y. – PersonEntity: Name: NameFull: Al‐Arifi, Renad – PersonEntity: Name: NameFull: Ovatlarnporn, Chitchamai – PersonEntity: Name: NameFull: AlYami, Khloud – PersonEntity: Name: NameFull: Rauf, Abdul – PersonEntity: Name: NameFull: Basit, Abdul – PersonEntity: Name: NameFull: Rao, Huma – PersonEntity: Name: NameFull: Batool, Maria – PersonEntity: Name: NameFull: Khan, Kashif ur Rehman IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20487177 Numbering: – Type: volume Value: 13 – Type: issue Value: 9 Titles: – TitleFull: Food Science & Nutrition Type: main |
| ResultId | 1 |
