Bioactive Potential and Health Benefits of Trigonella foenum‐graecum L.: A Comprehensive Review.

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Title: Bioactive Potential and Health Benefits of Trigonella foenum‐graecum L.: A Comprehensive Review.
Authors: Akhtar, Hassnain1 (AUTHOR), Ali, Yuosra Amer2 (AUTHOR) yuosra_amer@uomosul.edu.iq, Wei, Calvin R.3 (AUTHOR), Albassam, Reem S.4 (AUTHOR), Ahmed, Faiyaz5 (AUTHOR), Yasmin, Adeela1 (AUTHOR), Rasheed, Musarrat6 (AUTHOR), Naseer, Muhammad Sadiq7 (AUTHOR), Islam, Fakhar1,6 (AUTHOR) fakhar.ft440@gmail.com, Zahra, Syeda Mahvish8,9 (AUTHOR), Ndagire, Catherine Tamale10 (AUTHOR) catherinendagire@gmail.com
Source: Food Science & Nutrition. Sep2025, Vol. 13 Issue 9, p1-14. 14p.
Subject Terms: Fenugreek, Metabolic disorders, Phytochemicals, Antioxidants, Anti-inflammatory agents, Bioactive compounds, Treatment effectiveness
Abstract: Fenugreek seeds (Trigonella foenum‐graecum L.) are known for their impressive range of health benefits, thanks to their diverse array of phytochemicals. These include steroidal sapogenins like diosgenin, alkaloids such as trigonelline, as well as flavonoids, saponins, galactomannans, and polyphenols. Trigonella foenum‐graecum seeds contain mucilaginous fiber, which will tie bile acids and lower fat absorption and cholesterol. These bioactive constituents contribute to fenugreek's antioxidant, anti‐inflammatory, antinociceptive, antidiabetic, hypocholesterolemic, gastroprotective, antirheumatic, and antimicrobial activities. Alkaloids, 4‐Hydroxyisoleucine, and steroidal saponins have been shown to improve glucose metabolism and reduce cholesterol absorption. Additionally, specific chemical elements might excite insulin release from the B‐cells directly, resulting in a drop in blood glucose levels. Trigonella foenum‐graecum L. has also been found to have gastroprotective properties, antibacterial activities, and anticancer properties, and has been used to cure arthritis, lose weight, increase milk supply, and manage hyperthyroidism. Overall, fenugreek seeds represent a multi‐target natural agent with significant potential for managing metabolic disorders, inflammation, and related health conditions. Therefore, this paper aims to present the existing knowledge on the nutritional composition, bioactive potential, and health benefits in detail. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Bioactive Potential and Health Benefits of Trigonella foenum‐graecum L.: A Comprehensive Review.
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  Data: <searchLink fieldCode="AR" term="%22Akhtar%2C+Hassnain%22">Akhtar, Hassnain</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Yuosra+Amer%22">Ali, Yuosra Amer</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> yuosra_amer@uomosul.edu.iq</i><br /><searchLink fieldCode="AR" term="%22Wei%2C+Calvin+R%2E%22">Wei, Calvin R.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Albassam%2C+Reem+S%2E%22">Albassam, Reem S.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ahmed%2C+Faiyaz%22">Ahmed, Faiyaz</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yasmin%2C+Adeela%22">Yasmin, Adeela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rasheed%2C+Musarrat%22">Rasheed, Musarrat</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naseer%2C+Muhammad+Sadiq%22">Naseer, Muhammad Sadiq</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Islam%2C+Fakhar%22">Islam, Fakhar</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<i> fakhar.ft440@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Zahra%2C+Syeda+Mahvish%22">Zahra, Syeda Mahvish</searchLink><relatesTo>8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ndagire%2C+Catherine+Tamale%22">Ndagire, Catherine Tamale</searchLink><relatesTo>10</relatesTo> (AUTHOR)<i> catherinendagire@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Sep2025, Vol. 13 Issue 9, p1-14. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Fenugreek%22">Fenugreek</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+disorders%22">Metabolic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Phytochemicals%22">Phytochemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+compounds%22">Bioactive compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink>
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  Data: Fenugreek seeds (Trigonella foenum‐graecum L.) are known for their impressive range of health benefits, thanks to their diverse array of phytochemicals. These include steroidal sapogenins like diosgenin, alkaloids such as trigonelline, as well as flavonoids, saponins, galactomannans, and polyphenols. Trigonella foenum‐graecum seeds contain mucilaginous fiber, which will tie bile acids and lower fat absorption and cholesterol. These bioactive constituents contribute to fenugreek's antioxidant, anti‐inflammatory, antinociceptive, antidiabetic, hypocholesterolemic, gastroprotective, antirheumatic, and antimicrobial activities. Alkaloids, 4‐Hydroxyisoleucine, and steroidal saponins have been shown to improve glucose metabolism and reduce cholesterol absorption. Additionally, specific chemical elements might excite insulin release from the B‐cells directly, resulting in a drop in blood glucose levels. Trigonella foenum‐graecum L. has also been found to have gastroprotective properties, antibacterial activities, and anticancer properties, and has been used to cure arthritis, lose weight, increase milk supply, and manage hyperthyroidism. Overall, fenugreek seeds represent a multi‐target natural agent with significant potential for managing metabolic disorders, inflammation, and related health conditions. Therefore, this paper aims to present the existing knowledge on the nutritional composition, bioactive potential, and health benefits in detail. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/fsn3.70887
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      – Code: eng
        Text: English
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        PageCount: 14
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    Subjects:
      – SubjectFull: Fenugreek
        Type: general
      – SubjectFull: Metabolic disorders
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      – SubjectFull: Phytochemicals
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      – SubjectFull: Antioxidants
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      – SubjectFull: Anti-inflammatory agents
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      – SubjectFull: Bioactive compounds
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      – SubjectFull: Treatment effectiveness
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              Text: Sep2025
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