First trimester urine glyphosate concentrations and gestational diabetes in nulliparas: a nested case-control study.
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| Title: | First trimester urine glyphosate concentrations and gestational diabetes in nulliparas: a nested case-control study. |
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| Authors: | Haas, David M.1 (AUTHOR) dahaas@iu.edu, Moss, Kevin1 (AUTHOR), Faysal, Hani1 (AUTHOR), Yee, Lynn M.2 (AUTHOR), Silver, Robert M.3 (AUTHOR), Grobman, William A.4 (AUTHOR) |
| Source: | Environmental Health: A Global Access Science Source. 10/7/2025, Vol. 24 Issue 1, p1-9. 9p. |
| Subject Terms: | *Glyphosate, *Environmental exposure, Gestational diabetes, First trimester of pregnancy, Case-control method, Nulliparas, Body mass index |
| Abstract: | Background: Environmental exposures, such as pesticides, during pregnancy have been associated with several adverse pregnancy outcomes, including miscarriage and shorter gestational length at birth. However, their relationship with gestational diabetes (GDM) is uncertain. The objective of this study was to analyze first-trimester urinary herbicide concentrations for their associations with GDM. Methods: This was a nested case-control study analysis of the Nulliparous Pregnancy Outcomes Study- Monitoring Mothers-to-be (nuMoM2b) study. The study included participants at the three midwestern study sites. We analyzed individuals according to whether they developed GDM. Urinary herbicide concentration at the upper quartile was the exposure of interest. To assess the association of first-trimester urine glyphosate and metabolites with GDM, conditional logistic regression was used for matched pairs models. To test whether the association of herbicides with GDM was modified by BMI, an interaction term of herbicide (dichotomous variable) * BMI was included. Results: The 118 cases of nuMoM2b participants with GDM were matched with 118 randomly selected age-matched controls who had no adverse pregnancy outcomes. Participants with GDM were less likely to be Non-Hispanic White (26.3% vs. 40.7%; p = 0.02), had a higher mean BMI (30.7 ± 8.3 vs. 26.1 ± 6.3; p < 0.01), and were less likely to have graduated from college (55.1% vs. 72.0%; p = 0.007). Glyphosate concentrations were above the limit of detection (LOD) in 93.6% of analyzable samples. In the adjusted conditional logistic regression for the matched pairs model, participants with glyphosate in the upper quartile had significantly higher odds of having GDM (odds ratio [OR] 3.27, 95% confidence interval [CI] 1.04–10.3), with the OR of 1.23 (95% CI 1.02–1.47) for the interaction with BMI. Compared to participants with BMI < 25 kg/m2, the adjusted odds of GDM for participants with obese BMI (≥ 30 kg/m2) was elevated (OR 8.52, 95% CI 1.27–57.2). Conclusion: First trimester urinary glyphosate concentrations were associated with development of GDM, and the magnitude of this association increased at higher BMI. Trial registry: NCT01322529. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 188500002 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: First trimester urine glyphosate concentrations and gestational diabetes in nulliparas: a nested case-control study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Haas%2C+David+M%2E%22">Haas, David M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dahaas@iu.edu</i><br /><searchLink fieldCode="AR" term="%22Moss%2C+Kevin%22">Moss, Kevin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faysal%2C+Hani%22">Faysal, Hani</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yee%2C+Lynn+M%2E%22">Yee, Lynn M.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silver%2C+Robert+M%2E%22">Silver, Robert M.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grobman%2C+William+A%2E%22">Grobman, William A.</searchLink><relatesTo>4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 10/7/2025, Vol. 24 Issue 1, p1-9. 9p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Glyphosate%22">Glyphosate</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Gestational+diabetes%22">Gestational diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22First+trimester+of+pregnancy%22">First trimester of pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Nulliparas%22">Nulliparas</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Environmental exposures, such as pesticides, during pregnancy have been associated with several adverse pregnancy outcomes, including miscarriage and shorter gestational length at birth. However, their relationship with gestational diabetes (GDM) is uncertain. The objective of this study was to analyze first-trimester urinary herbicide concentrations for their associations with GDM. Methods: This was a nested case-control study analysis of the Nulliparous Pregnancy Outcomes Study- Monitoring Mothers-to-be (nuMoM2b) study. The study included participants at the three midwestern study sites. We analyzed individuals according to whether they developed GDM. Urinary herbicide concentration at the upper quartile was the exposure of interest. To assess the association of first-trimester urine glyphosate and metabolites with GDM, conditional logistic regression was used for matched pairs models. To test whether the association of herbicides with GDM was modified by BMI, an interaction term of herbicide (dichotomous variable) * BMI was included. Results: The 118 cases of nuMoM2b participants with GDM were matched with 118 randomly selected age-matched controls who had no adverse pregnancy outcomes. Participants with GDM were less likely to be Non-Hispanic White (26.3% vs. 40.7%; p = 0.02), had a higher mean BMI (30.7 ± 8.3 vs. 26.1 ± 6.3; p < 0.01), and were less likely to have graduated from college (55.1% vs. 72.0%; p = 0.007). Glyphosate concentrations were above the limit of detection (LOD) in 93.6% of analyzable samples. In the adjusted conditional logistic regression for the matched pairs model, participants with glyphosate in the upper quartile had significantly higher odds of having GDM (odds ratio [OR] 3.27, 95% confidence interval [CI] 1.04–10.3), with the OR of 1.23 (95% CI 1.02–1.47) for the interaction with BMI. Compared to participants with BMI < 25 kg/m2, the adjusted odds of GDM for participants with obese BMI (≥ 30 kg/m2) was elevated (OR 8.52, 95% CI 1.27–57.2). Conclusion: First trimester urinary glyphosate concentrations were associated with development of GDM, and the magnitude of this association increased at higher BMI. Trial registry: NCT01322529. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=188500002 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12940-025-01183-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Glyphosate Type: general – SubjectFull: Environmental exposure Type: general – SubjectFull: Gestational diabetes Type: general – SubjectFull: First trimester of pregnancy Type: general – SubjectFull: Case-control method Type: general – SubjectFull: Nulliparas Type: general – SubjectFull: Body mass index Type: general Titles: – TitleFull: First trimester urine glyphosate concentrations and gestational diabetes in nulliparas: a nested case-control study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Haas, David M. – PersonEntity: Name: NameFull: Moss, Kevin – PersonEntity: Name: NameFull: Faysal, Hani – PersonEntity: Name: NameFull: Yee, Lynn M. – PersonEntity: Name: NameFull: Silver, Robert M. – PersonEntity: Name: NameFull: Grobman, William A. IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 10 Text: 10/7/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 1476069X Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: Environmental Health: A Global Access Science Source Type: main |
| ResultId | 1 |
