Double-edged implications of triclosan for the neuroendocrine system: evidence from the national health and nutrition examination survey (2011–2014 NHANES).
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| Title: | Double-edged implications of triclosan for the neuroendocrine system: evidence from the national health and nutrition examination survey (2011–2014 NHANES). |
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| Authors: | Li, Zhiming1 (AUTHOR), Ma, Lichun1 (AUTHOR), Zhong, Yizhou1 (AUTHOR), Liang, Boxuan1 (AUTHOR), Huang, Yuji1 (AUTHOR), Huang, Zhenlie1 (AUTHOR) huangzhenlie858252@smu.edu.cn |
| Source: | Environmental Science: Processes & Impacts. Oct2025, Vol. 27 Issue 10, p3095-3106. 12p. |
| Subject Terms: | *Endocrine disruptors, Triclosan, Neuroendocrine system, Mental health, Statistical correlation, National Health & Nutrition Examination Survey, Cognitive ability |
| Geographic Terms: | United States |
| Abstract: | Triclosan (TCS) has raised concerns due to its widespread use and potential neuroendocrine toxicity. However, its neurological effects and the interplay between TCS-induced sex hormone disruption and neurological outcomes in adults remain largely unexplored. Herein, we analyzed data from 2717 adults in the 2011–2014 National Health and Nutrition Examination Survey, employing logistic regression, restricted cubic spline, and mediation analyses to investigate the association between TCS exposure and neurological outcomes. The results showed that higher TCS exposure (above the median) was associated with lower odds of poor cognitive performance on the digit symbol substitution test (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.42–0.99, P = 0.046), depression (OR = 0.68, 95% CI = 0.49–0.93, P = 0.015), and serious difficulty in concentrating (OR = 0.47, 95% CI = 0.30–0.74, P = 0.001). Mediation analyses revealed that testosterone and white blood cell counts partially mediated the relationship between TCS exposure and neurological outcomes. Additionally, gender-specific and U-shaped associations were observed between TCS exposure and cognitive function, depression, and difficulty concentrating. Collectively, our findings provide the first evidence linking TCS exposure to neurological health outcomes and potential neurotoxicity via sex hormone disruption in U.S. adults. Further research is needed to elucidate the underlying mechanisms and clinical significance of these associations. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Science: Processes & Impacts is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
| FullText | Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 188674897 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Double-edged implications of triclosan for the neuroendocrine system: evidence from the national health and nutrition examination survey (2011–2014 NHANES). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Zhiming%22">Li, Zhiming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Lichun%22">Ma, Lichun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Yizhou%22">Zhong, Yizhou</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liang%2C+Boxuan%22">Liang, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yuji%22">Huang, Yuji</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Zhenlie%22">Huang, Zhenlie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> huangzhenlie858252@smu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Science%3A+Processes+%26+Impacts%22">Environmental Science: Processes & Impacts</searchLink>. Oct2025, Vol. 27 Issue 10, p3095-3106. 12p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Endocrine+disruptors%22">Endocrine disruptors</searchLink><br /><searchLink fieldCode="DE" term="%22Triclosan%22">Triclosan</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroendocrine+system%22">Neuroendocrine system</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br /><searchLink fieldCode="DE" term="%22National+Health+%26+Nutrition+Examination+Survey%22">National Health & Nutrition Examination Survey</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Triclosan (TCS) has raised concerns due to its widespread use and potential neuroendocrine toxicity. However, its neurological effects and the interplay between TCS-induced sex hormone disruption and neurological outcomes in adults remain largely unexplored. Herein, we analyzed data from 2717 adults in the 2011–2014 National Health and Nutrition Examination Survey, employing logistic regression, restricted cubic spline, and mediation analyses to investigate the association between TCS exposure and neurological outcomes. The results showed that higher TCS exposure (above the median) was associated with lower odds of poor cognitive performance on the digit symbol substitution test (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.42–0.99, P = 0.046), depression (OR = 0.68, 95% CI = 0.49–0.93, P = 0.015), and serious difficulty in concentrating (OR = 0.47, 95% CI = 0.30–0.74, P = 0.001). Mediation analyses revealed that testosterone and white blood cell counts partially mediated the relationship between TCS exposure and neurological outcomes. Additionally, gender-specific and U-shaped associations were observed between TCS exposure and cognitive function, depression, and difficulty concentrating. Collectively, our findings provide the first evidence linking TCS exposure to neurological health outcomes and potential neurotoxicity via sex hormone disruption in U.S. adults. Further research is needed to elucidate the underlying mechanisms and clinical significance of these associations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Science: Processes & Impacts is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5em00332f Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 3095 Subjects: – SubjectFull: Endocrine disruptors Type: general – SubjectFull: Triclosan Type: general – SubjectFull: Neuroendocrine system Type: general – SubjectFull: Mental health Type: general – SubjectFull: Statistical correlation Type: general – SubjectFull: National Health & Nutrition Examination Survey Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: United States Type: general Titles: – TitleFull: Double-edged implications of triclosan for the neuroendocrine system: evidence from the national health and nutrition examination survey (2011–2014 NHANES). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Zhiming – PersonEntity: Name: NameFull: Ma, Lichun – PersonEntity: Name: NameFull: Zhong, Yizhou – PersonEntity: Name: NameFull: Liang, Boxuan – PersonEntity: Name: NameFull: Huang, Yuji – PersonEntity: Name: NameFull: Huang, Zhenlie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20507887 Numbering: – Type: volume Value: 27 – Type: issue Value: 10 Titles: – TitleFull: Environmental Science: Processes & Impacts Type: main |
| ResultId | 1 |
