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Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children.

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Title: Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children.
Authors: Wilson, Kyle J.1,2 kyle.wilson@liverpool.ac.uk, Tu, Zhanhan3 zhanhan.tu@leicester.ac.uk, Mbale, Emmie4, Mhango, Priscilla P.5, Kayange, Petros5, Gladstone, Melissa J.6, Harding, Simon1,7, Gottlob, Irene8, Garcia-Finana, Marta9, Shen, Yaochun10, Taylor, Terrie E.11,12, Seydel, Karl B.11,12, Zheng, Yalin1,13, Beare, Nicholas A. V.1,7 nbeare@liverpool.ac.uk
Source: Wellcome Open Research. 2023, p1-14. 14p.
Subject Terms: Cerebral malaria, Optical coherence tomography, Intracranial pressure, Brain diseases, Artificial intelligence
Abstract: Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity. Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis. [ABSTRACT FROM AUTHOR]
Copyright of Wellcome Open Research is the property of Wellcome Trust and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children.
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  Data: <searchLink fieldCode="AR" term="%22Wilson%2C+Kyle+J%2E%22">Wilson, Kyle J.</searchLink><relatesTo>1,2</relatesTo><i> kyle.wilson@liverpool.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Tu%2C+Zhanhan%22">Tu, Zhanhan</searchLink><relatesTo>3</relatesTo><i> zhanhan.tu@leicester.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Mbale%2C+Emmie%22">Mbale, Emmie</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Mhango%2C+Priscilla+P%2E%22">Mhango, Priscilla P.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Kayange%2C+Petros%22">Kayange, Petros</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Gladstone%2C+Melissa+J%2E%22">Gladstone, Melissa J.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Harding%2C+Simon%22">Harding, Simon</searchLink><relatesTo>1,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Gottlob%2C+Irene%22">Gottlob, Irene</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Garcia-Finana%2C+Marta%22">Garcia-Finana, Marta</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Shen%2C+Yaochun%22">Shen, Yaochun</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Taylor%2C+Terrie+E%2E%22">Taylor, Terrie E.</searchLink><relatesTo>11,12</relatesTo><br /><searchLink fieldCode="AR" term="%22Seydel%2C+Karl+B%2E%22">Seydel, Karl B.</searchLink><relatesTo>11,12</relatesTo><br /><searchLink fieldCode="AR" term="%22Zheng%2C+Yalin%22">Zheng, Yalin</searchLink><relatesTo>1,13</relatesTo><br /><searchLink fieldCode="AR" term="%22Beare%2C+Nicholas+A%2E+V%2E%22">Beare, Nicholas A. V.</searchLink><relatesTo>1,7</relatesTo><i> nbeare@liverpool.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Wellcome+Open+Research%22">Wellcome Open Research</searchLink>. 2023, p1-14. 14p.
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  Data: Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity. Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Wellcome Open Research is the property of Wellcome Trust and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.12688/wellcomeopenres.19166.1
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        Text: English
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        PageCount: 14
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      – SubjectFull: Cerebral malaria
        Type: general
      – SubjectFull: Optical coherence tomography
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      – SubjectFull: Intracranial pressure
        Type: general
      – SubjectFull: Brain diseases
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      – SubjectFull: Artificial intelligence
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      – TitleFull: Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children.
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              Text: 2023
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