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Anti‐Obesity Effects Exerted by Achyranthes bidentata Polysaccharides in Diet‐Induced Obese Mice.

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Title: Anti‐Obesity Effects Exerted by Achyranthes bidentata Polysaccharides in Diet‐Induced Obese Mice.
Authors: Li, Sheng‐Nan1,2 (AUTHOR) lsn@hpu.edu.cn, Zhang, Wen‐Kui1,2 (AUTHOR), Liu, Yi‐Man1 (AUTHOR), Shi, Wen1 (AUTHOR), Zhang, Yang‐Chao1 (AUTHOR), Li, Xue‐Yu1 (AUTHOR), Jin, Lin‐Ang1 (AUTHOR), Cui, Meng‐Jie1 (AUTHOR), Li, Yan‐Ran1 (AUTHOR), Chen, Wen‐Bo1,2 (AUTHOR) chenwenbo@hpu.edu.cn
Source: Food Science & Nutrition. Nov2025, Vol. 13 Issue 11, p1-13. 13p.
Subject Terms: Antiobesity agents, Polysaccharides, High-fat diet, Liver injuries, Gut microbiota, Insulin resistance, Inflammation
Abstract: Obesity involves persistent inflammation, insulin resistance, and disturbances in gut microbiota. Achyranthes bidentata, a plant long used in Chinese medicine, contains polysaccharides with bioactive properties. This study investigates polysaccharides isolated from its water extract (ABPs) consisting of 41.83% Glucose, 40.75% Galacturonic Acid, 7.86% Arabinose, 6.11% Galactose and 3.45% Rhamnose, which were prepared. We showed that ABPs mitigated obesity, decreased insulin resistance, alleviated inflammation, and relieved hepatic damage in high‐fat diet (HFD)‐fed mice. Specifically, ABPs regulated glucose levels by downregulating GLUT1 and upregulating PGC‐1α, and significantly reduced the expression of key genes related to adipogenesis and metabolism (PPARα, PPARγ, C/EBPα, and SOX4) in obese mice. Subsequent studies revealed that ABPs could alter the gut microbiota profile and increase short‐chain fatty acids (SCFAs) levels in mice on an HFD. Treatment with ABPs reduced the Firmicutes: Bacteroidota ratio and declined the abundances of intestinal bacteria including Intestinimonas, Lachnospiraceae_unclassified and Oscillibacter. ABPs supplementation significantly restored the diet‐induced imbalance of SCFAs in HFD‐fed mice, notably reversing the reduction in propionic acid. This suggests that ABPs exert obvious anti‐obesity activities, by suppressing systematic inflammation, improving hepatic metabolism, while concurrently ameliorating gut microbiota dysregulation in obese mice. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Anti‐Obesity Effects Exerted by Achyranthes bidentata Polysaccharides in Diet‐Induced Obese Mice.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Sheng‐Nan%22">Li, Sheng‐Nan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lsn@hpu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Wen‐Kui%22">Zhang, Wen‐Kui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yi‐Man%22">Liu, Yi‐Man</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Wen%22">Shi, Wen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yang‐Chao%22">Zhang, Yang‐Chao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xue‐Yu%22">Li, Xue‐Yu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jin%2C+Lin‐Ang%22">Jin, Lin‐Ang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Meng‐Jie%22">Cui, Meng‐Jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yan‐Ran%22">Li, Yan‐Ran</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Wen‐Bo%22">Chen, Wen‐Bo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> chenwenbo@hpu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Nov2025, Vol. 13 Issue 11, p1-13. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Antiobesity+agents%22">Antiobesity agents</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22High-fat+diet%22">High-fat diet</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+injuries%22">Liver injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+resistance%22">Insulin resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Obesity involves persistent inflammation, insulin resistance, and disturbances in gut microbiota. Achyranthes bidentata, a plant long used in Chinese medicine, contains polysaccharides with bioactive properties. This study investigates polysaccharides isolated from its water extract (ABPs) consisting of 41.83% Glucose, 40.75% Galacturonic Acid, 7.86% Arabinose, 6.11% Galactose and 3.45% Rhamnose, which were prepared. We showed that ABPs mitigated obesity, decreased insulin resistance, alleviated inflammation, and relieved hepatic damage in high‐fat diet (HFD)‐fed mice. Specifically, ABPs regulated glucose levels by downregulating GLUT1 and upregulating PGC‐1α, and significantly reduced the expression of key genes related to adipogenesis and metabolism (PPARα, PPARγ, C/EBPα, and SOX4) in obese mice. Subsequent studies revealed that ABPs could alter the gut microbiota profile and increase short‐chain fatty acids (SCFAs) levels in mice on an HFD. Treatment with ABPs reduced the Firmicutes: Bacteroidota ratio and declined the abundances of intestinal bacteria including Intestinimonas, Lachnospiraceae_unclassified and Oscillibacter. ABPs supplementation significantly restored the diet‐induced imbalance of SCFAs in HFD‐fed mice, notably reversing the reduction in propionic acid. This suggests that ABPs exert obvious anti‐obesity activities, by suppressing systematic inflammation, improving hepatic metabolism, while concurrently ameliorating gut microbiota dysregulation in obese mice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/fsn3.71185
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Antiobesity agents
        Type: general
      – SubjectFull: Polysaccharides
        Type: general
      – SubjectFull: High-fat diet
        Type: general
      – SubjectFull: Liver injuries
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      – SubjectFull: Gut microbiota
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      – SubjectFull: Insulin resistance
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      – SubjectFull: Inflammation
        Type: general
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      – TitleFull: Anti‐Obesity Effects Exerted by Achyranthes bidentata Polysaccharides in Diet‐Induced Obese Mice.
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              Text: Nov2025
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