Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease‐Induced Selection in Wild White‐Tailed Deer.
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| Title: | Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease‐Induced Selection in Wild White‐Tailed Deer. |
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| Authors: | Bubac, Christine M.1,2 (AUTHOR) christinebubac@cunet.carleton.ca, Russell, Ty2 (AUTHOR), McKenzie, Debbie2 (AUTHOR), Ball, Mark C.3 (AUTHOR), Pybus, Margo J.2,3 (AUTHOR), Coltman, David W.2,4 (AUTHOR), Cullingham, Catherine I.1,2 (AUTHOR) |
| Source: | Ecology & Evolution (20457758). Nov2025, Vol. 15 Issue 11, p1-13. 13p. |
| Subject Terms: | *Chronic wasting disease, Genetic variation, Genetic polymorphisms, Spatial variation, White-tailed deer, Prion diseases, Natural selection |
| Geographic Terms: | Northern Alberta, Canada, North America |
| Abstract: | Chronic wasting disease (CWD) poses a threat to cervids and is increasingly prevalent throughout North America. Prion protein gene (PRNP) variation may confer some degree of genetic resilience, creating an impetus to examine changes in allelic variation and to assess signatures of selection. We investigated the association between CWD and PRNP variation in white‐tailed deer (WTD) (Odocoileus virginianus) and mule deer (MD) (Odocoileus hemionus) sampled in Alberta, Canada between 2014 and 2017. We sequenced the PRNP gene of 575 WTD (67 CWD‐positives) and 660 MD (202 CWD‐positives) and detected 14 single nucleotide polymorphic loci in WTD and 8 in MD. No association was identified between the MD genetic variation and disease status. Notably, a variant at 286 was detected in WTD, resulting in an amino acid change at codon 96 (G96S). Genotype counts at this locus were significantly associated with CWD status, with the 96S allele under‐represented among CWD‐positive and over‐represented among negative individuals. For a CWD‐positive individual, the odds of being homozygous for the major allele (G96/G96) were more than sevenfold greater than being homozygous for the minor allele (96S/96S). Following additional sequencing of 1612 WTD, we examined spatial and temporal variability of this locus in association with the disease history on the landscape. Among females, the frequency of 96S varied negatively with the distance to where CWD was first detected. Additionally, the 96S allele frequency has increased over time, in line with expectations based on estimated disease selection coefficients. Our results are consistent with CWD selection pressure resulting in increasing frequency of the 96S allele in space and time, indicating it may confer some resilience and extended infection with CWD. [ABSTRACT FROM AUTHOR] |
| Copyright of Ecology & Evolution (20457758) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 189710376 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease‐Induced Selection in Wild White‐Tailed Deer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bubac%2C+Christine+M%2E%22">Bubac, Christine M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> christinebubac@cunet.carleton.ca</i><br /><searchLink fieldCode="AR" term="%22Russell%2C+Ty%22">Russell, Ty</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McKenzie%2C+Debbie%22">McKenzie, Debbie</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ball%2C+Mark+C%2E%22">Ball, Mark C.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pybus%2C+Margo+J%2E%22">Pybus, Margo J.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coltman%2C+David+W%2E%22">Coltman, David W.</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cullingham%2C+Catherine+I%2E%22">Cullingham, Catherine I.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Ecology+%26+Evolution+%2820457758%29%22">Ecology & Evolution (20457758)</searchLink>. Nov2025, Vol. 15 Issue 11, p1-13. 13p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Chronic+wasting+disease%22">Chronic wasting disease</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+variation%22">Spatial variation</searchLink><br /><searchLink fieldCode="DE" term="%22White-tailed+deer%22">White-tailed deer</searchLink><br /><searchLink fieldCode="DE" term="%22Prion+diseases%22">Prion diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Natural+selection%22">Natural selection</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Northern+Alberta%22">Northern Alberta</searchLink><br /><searchLink fieldCode="DE" term="%22Canada%22">Canada</searchLink><br /><searchLink fieldCode="DE" term="%22North+America%22">North America</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Chronic wasting disease (CWD) poses a threat to cervids and is increasingly prevalent throughout North America. Prion protein gene (PRNP) variation may confer some degree of genetic resilience, creating an impetus to examine changes in allelic variation and to assess signatures of selection. We investigated the association between CWD and PRNP variation in white‐tailed deer (WTD) (Odocoileus virginianus) and mule deer (MD) (Odocoileus hemionus) sampled in Alberta, Canada between 2014 and 2017. We sequenced the PRNP gene of 575 WTD (67 CWD‐positives) and 660 MD (202 CWD‐positives) and detected 14 single nucleotide polymorphic loci in WTD and 8 in MD. No association was identified between the MD genetic variation and disease status. Notably, a variant at 286 was detected in WTD, resulting in an amino acid change at codon 96 (G96S). Genotype counts at this locus were significantly associated with CWD status, with the 96S allele under‐represented among CWD‐positive and over‐represented among negative individuals. For a CWD‐positive individual, the odds of being homozygous for the major allele (G96/G96) were more than sevenfold greater than being homozygous for the minor allele (96S/96S). Following additional sequencing of 1612 WTD, we examined spatial and temporal variability of this locus in association with the disease history on the landscape. Among females, the frequency of 96S varied negatively with the distance to where CWD was first detected. Additionally, the 96S allele frequency has increased over time, in line with expectations based on estimated disease selection coefficients. Our results are consistent with CWD selection pressure resulting in increasing frequency of the 96S allele in space and time, indicating it may confer some resilience and extended infection with CWD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Ecology & Evolution (20457758) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ece3.72449 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Chronic wasting disease Type: general – SubjectFull: Genetic variation Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Spatial variation Type: general – SubjectFull: White-tailed deer Type: general – SubjectFull: Prion diseases Type: general – SubjectFull: Natural selection Type: general – SubjectFull: Northern Alberta Type: general – SubjectFull: Canada Type: general – SubjectFull: North America Type: general Titles: – TitleFull: Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease‐Induced Selection in Wild White‐Tailed Deer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bubac, Christine M. – PersonEntity: Name: NameFull: Russell, Ty – PersonEntity: Name: NameFull: McKenzie, Debbie – PersonEntity: Name: NameFull: Ball, Mark C. – PersonEntity: Name: NameFull: Pybus, Margo J. – PersonEntity: Name: NameFull: Coltman, David W. – PersonEntity: Name: NameFull: Cullingham, Catherine I. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20457758 Numbering: – Type: volume Value: 15 – Type: issue Value: 11 Titles: – TitleFull: Ecology & Evolution (20457758) Type: main |
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