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Safety evaluation of the food enzyme β‐fructofuranosidase from the non‐genetically modified Aspergillus sp. strain ATCC 20611.

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Title: Safety evaluation of the food enzyme β‐fructofuranosidase from the non‐genetically modified Aspergillus sp. strain ATCC 20611.
Authors: Zorn, Holger (AUTHOR), Barat Baviera, José Manuel (AUTHOR), Bolognesi, Claudia (AUTHOR), Catania, Francesco (AUTHOR), Gadermaier, Gabriele (AUTHOR), Greiner, Ralf (AUTHOR), Mayo, Baltasar (AUTHOR), Mortensen, Alicja (AUTHOR), Roos, Yrjö Henrik (AUTHOR), Solano, Marize L. M. (AUTHOR), Van Loveren, Henk (AUTHOR), Vernis, Laurence (AUTHOR), Criado, Ana (AUTHOR), Peluso, Silvia (AUTHOR), Andryszkiewicz, Magdalena (AUTHOR), Cavanna, Daniele (AUTHOR), Lunardi, Simone (AUTHOR), Liu, Yi (AUTHOR)
Source: EFSA Journal. Jan2026, Vol. 24 Issue 1, p1-11. 11p.
Subject Terms: *Experimental toxicology, *Food safety, *Allergies, Enzymes, Safety, Oligosaccharides, Invertase, Aspergillus
Abstract: The food enzyme β‐fructofuranosidase (β‐d‐fructofuranoside fructohydrolase; EC 3.2.1.26) is produced with the non‐genetically modified Aspergillus sp. strain ATCC 20611 by Beghin Meiji. The food enzyme was free from viable cells of the production organism. It is intended to be used in the processing of sugars for the production of fructo‐oligosaccharides (FOS). Since residual amounts of total organic solids of the food enzyme are removed in FOS syrups, dietary exposure was not calculated. The toxicological studies were assessed as supportive evidence. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 920 mg TOS/kg body weight (bw) per day, the highest dose tested. A search for the homology of the amino acid sequence of the β‐fructofuranosidase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure to the food enzyme cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety evaluation of the food enzyme β‐fructofuranosidase from the non‐genetically modified Aspergillus sp. strain ATCC 20611.
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  Data: <searchLink fieldCode="AR" term="%22Zorn%2C+Holger%22">Zorn, Holger</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barat+Baviera%2C+José+Manuel%22">Barat Baviera, José Manuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bolognesi%2C+Claudia%22">Bolognesi, Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Catania%2C+Francesco%22">Catania, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gadermaier%2C+Gabriele%22">Gadermaier, Gabriele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greiner%2C+Ralf%22">Greiner, Ralf</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayo%2C+Baltasar%22">Mayo, Baltasar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mortensen%2C+Alicja%22">Mortensen, Alicja</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roos%2C+Yrjö+Henrik%22">Roos, Yrjö Henrik</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solano%2C+Marize+L%2E+M%2E%22">Solano, Marize L. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Loveren%2C+Henk%22">Van Loveren, Henk</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vernis%2C+Laurence%22">Vernis, Laurence</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Criado%2C+Ana%22">Criado, Ana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peluso%2C+Silvia%22">Peluso, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andryszkiewicz%2C+Magdalena%22">Andryszkiewicz, Magdalena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavanna%2C+Daniele%22">Cavanna, Daniele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lunardi%2C+Simone%22">Lunardi, Simone</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yi%22">Liu, Yi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22EFSA+Journal%22">EFSA Journal</searchLink>. Jan2026, Vol. 24 Issue 1, p1-11. 11p.
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  Data: The food enzyme β‐fructofuranosidase (β‐d‐fructofuranoside fructohydrolase; EC 3.2.1.26) is produced with the non‐genetically modified Aspergillus sp. strain ATCC 20611 by Beghin Meiji. The food enzyme was free from viable cells of the production organism. It is intended to be used in the processing of sugars for the production of fructo‐oligosaccharides (FOS). Since residual amounts of total organic solids of the food enzyme are removed in FOS syrups, dietary exposure was not calculated. The toxicological studies were assessed as supportive evidence. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 920 mg TOS/kg body weight (bw) per day, the highest dose tested. A search for the homology of the amino acid sequence of the β‐fructofuranosidase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure to the food enzyme cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.2903/j.efsa.2026.9833
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      – Code: eng
        Text: English
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        PageCount: 11
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      – SubjectFull: Experimental toxicology
        Type: general
      – SubjectFull: Food safety
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      – SubjectFull: Allergies
        Type: general
      – SubjectFull: Enzymes
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      – SubjectFull: Safety
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      – SubjectFull: Oligosaccharides
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      – SubjectFull: Invertase
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      – SubjectFull: Aspergillus
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