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Assessment of genetically modified soybean GMB151 × DAS‐44406‐6 (application GMFF‐2024‐21774, EFSA‐Q‐2024‐00330).

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Title: Assessment of genetically modified soybean GMB151 × DAS‐44406‐6 (application GMFF‐2024‐21774, EFSA‐Q‐2024‐00330).
Authors: Casacuberta, Josep (AUTHOR), Barro, Francisco (AUTHOR), Braeuning, Albert (AUTHOR), de Maagd, Ruud (AUTHOR), Epstein, Michelle M. (AUTHOR), Frenzel, Thomas (AUTHOR), Gallois, Jean‐Luc (AUTHOR), Koning, Frits (AUTHOR), Messéan, Antoine (AUTHOR), Moreno, F. Javier (AUTHOR), Nogué, Fabien (AUTHOR), Savoini, Giovanni (AUTHOR), Schulman, Alan H. (AUTHOR), Tebbe, Christoph (AUTHOR), Veromann, Eve (AUTHOR), Ardizzone, Michele (AUTHOR), De Sanctis, Giacomo (AUTHOR), Dumont, Antonio Fernandez (AUTHOR), Ferrari, Arianna (AUTHOR), Gennaro, Andrea (AUTHOR)
Source: EFSA Journal. Jan2026, Vol. 24 Issue 1, p1-37. 37p.
Subject Terms: *Toxicity testing, *Herbicide tolerance of plants, *Biosafety, Safety, Soybean, Plant nematodes, Soy proteins
Abstract: Genetically modified soybean GMB151 × DAS‐44406‐6 was developed by crossing to combine two single events: GMB151 and DAS‐44406‐6. The two‐event stack soybean expresses the Cry14Ab‐1, HPPD‐4, PAT, AAD‐12 and 2mEPSPS proteins to confer herbicide tolerance and resistance to plant parasitic nematodes. The GMO Panel previously assessed the two single soybean events and did not identify safety concerns. No new data on the single soybean events were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single soybean events and of the newly expressed proteins in the two‐event stack soybean does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that two‐event stack soybean, as described in this application, is as safe as the comparator and non‐GM reference soybean varieties tested and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of GM two‐event stack soybean material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of soybean GMB151 × DAS‐44406‐6. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that two‐event stack soybean is as safe as its comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Assessment of genetically modified soybean GMB151 × DAS‐44406‐6 (application GMFF‐2024‐21774, EFSA‐Q‐2024‐00330).
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  Data: <searchLink fieldCode="AR" term="%22Casacuberta%2C+Josep%22">Casacuberta, Josep</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barro%2C+Francisco%22">Barro, Francisco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Braeuning%2C+Albert%22">Braeuning, Albert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Maagd%2C+Ruud%22">de Maagd, Ruud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Epstein%2C+Michelle+M%2E%22">Epstein, Michelle M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frenzel%2C+Thomas%22">Frenzel, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gallois%2C+Jean‐Luc%22">Gallois, Jean‐Luc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koning%2C+Frits%22">Koning, Frits</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Messéan%2C+Antoine%22">Messéan, Antoine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreno%2C+F%2E+Javier%22">Moreno, F. Javier</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nogué%2C+Fabien%22">Nogué, Fabien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savoini%2C+Giovanni%22">Savoini, Giovanni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulman%2C+Alan+H%2E%22">Schulman, Alan H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tebbe%2C+Christoph%22">Tebbe, Christoph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Veromann%2C+Eve%22">Veromann, Eve</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ardizzone%2C+Michele%22">Ardizzone, Michele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Sanctis%2C+Giacomo%22">De Sanctis, Giacomo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dumont%2C+Antonio+Fernandez%22">Dumont, Antonio Fernandez</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrari%2C+Arianna%22">Ferrari, Arianna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gennaro%2C+Andrea%22">Gennaro, Andrea</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22EFSA+Journal%22">EFSA Journal</searchLink>. Jan2026, Vol. 24 Issue 1, p1-37. 37p.
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  Data: *<searchLink fieldCode="DE" term="%22Toxicity+testing%22">Toxicity testing</searchLink><br />*<searchLink fieldCode="DE" term="%22Herbicide+tolerance+of+plants%22">Herbicide tolerance of plants</searchLink><br />*<searchLink fieldCode="DE" term="%22Biosafety%22">Biosafety</searchLink><br /><searchLink fieldCode="DE" term="%22Safety%22">Safety</searchLink><br /><searchLink fieldCode="DE" term="%22Soybean%22">Soybean</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+nematodes%22">Plant nematodes</searchLink><br /><searchLink fieldCode="DE" term="%22Soy+proteins%22">Soy proteins</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Genetically modified soybean GMB151 × DAS‐44406‐6 was developed by crossing to combine two single events: GMB151 and DAS‐44406‐6. The two‐event stack soybean expresses the Cry14Ab‐1, HPPD‐4, PAT, AAD‐12 and 2mEPSPS proteins to confer herbicide tolerance and resistance to plant parasitic nematodes. The GMO Panel previously assessed the two single soybean events and did not identify safety concerns. No new data on the single soybean events were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single soybean events and of the newly expressed proteins in the two‐event stack soybean does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that two‐event stack soybean, as described in this application, is as safe as the comparator and non‐GM reference soybean varieties tested and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of GM two‐event stack soybean material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of soybean GMB151 × DAS‐44406‐6. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that two‐event stack soybean is as safe as its comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.2903/j.efsa.2026.9844
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      – Code: eng
        Text: English
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      – SubjectFull: Toxicity testing
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      – SubjectFull: Herbicide tolerance of plants
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      – SubjectFull: Soy proteins
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