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Gastrodia elata–Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism.

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Title: Gastrodia elata–Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism.
Authors: Li, Zhu1,2 (AUTHOR) 20240003@ztu.edu.cn, Chen, Yue1,2 (AUTHOR), Shi, Huihuang1,2 (AUTHOR), Tang, Peng1,2 (AUTHOR), Zhang, Xiangui1,2 (AUTHOR)
Source: Food Science & Nutrition. Apr2026, Vol. 14 Issue 4, p1-20. 20p.
Subject Terms: *Plant extracts, *Apoptosis, Aging prevention, Oxidative stress, Inflammation, Orchids, Metabolism, Cognitive ability
Abstract: This study investigates the anti‐aging properties of Gastrodia elata‐derived Parishin extracts (GEPE) by exploring its regulatory effects on oxidative stress, inflammatory responses, apoptosis, and metabolism. Network pharmacology identified 27 active components with parishins as core and 250 anti‐aging intersection targets of Gastrodia elata. Molecular docking confirmed strong binding activity of parishins to key targets such as EGFR, AKT1, and ALB. In vitro experiments showed that the GEPE concentration dependently reduced the activity of senescence marker SA‐β‐gal in D‐galactose‐induced senescent mouse microglial cell (BV2). In vivo experiments showed that GEPE improved cognitive and muscle functions, elevated organ indices of liver, thymus, and spleen, alleviated hepatic lipid accumulation and neuronal damage, reduced oxidative stress, inhibited inflammatory responses and cell apoptosis, and corrected metabolic disorders in D‐galactose‐induced aging mice. These findings demonstrate that GEPE is associated with attenuated aging, potentially through coordinated modulation of oxidative stress, inflammation, apoptosis, and metabolic homeostasis, highlighting its potential as a candidate for anti‐aging interventions. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Gastrodia elata–Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Zhu%22">Li, Zhu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> 20240003@ztu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Chen%2C+Yue%22">Chen, Yue</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Huihuang%22">Shi, Huihuang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Peng%22">Tang, Peng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiangui%22">Zhang, Xiangui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Apr2026, Vol. 14 Issue 4, p1-20. 20p.
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  Data: *<searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br />*<searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Aging+prevention%22">Aging prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Orchids%22">Orchids</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolism%22">Metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink>
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  Label: Abstract
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  Data: This study investigates the anti‐aging properties of Gastrodia elata‐derived Parishin extracts (GEPE) by exploring its regulatory effects on oxidative stress, inflammatory responses, apoptosis, and metabolism. Network pharmacology identified 27 active components with parishins as core and 250 anti‐aging intersection targets of Gastrodia elata. Molecular docking confirmed strong binding activity of parishins to key targets such as EGFR, AKT1, and ALB. In vitro experiments showed that the GEPE concentration dependently reduced the activity of senescence marker SA‐β‐gal in D‐galactose‐induced senescent mouse microglial cell (BV2). In vivo experiments showed that GEPE improved cognitive and muscle functions, elevated organ indices of liver, thymus, and spleen, alleviated hepatic lipid accumulation and neuronal damage, reduced oxidative stress, inhibited inflammatory responses and cell apoptosis, and corrected metabolic disorders in D‐galactose‐induced aging mice. These findings demonstrate that GEPE is associated with attenuated aging, potentially through coordinated modulation of oxidative stress, inflammation, apoptosis, and metabolic homeostasis, highlighting its potential as a candidate for anti‐aging interventions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/fsn3.71737
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        Text: English
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      – SubjectFull: Plant extracts
        Type: general
      – SubjectFull: Apoptosis
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      – SubjectFull: Aging prevention
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      – SubjectFull: Orchids
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      – SubjectFull: Cognitive ability
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      – TitleFull: Gastrodia elata–Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism.
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            NameFull: Li, Zhu
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              Text: Apr2026
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              Y: 2026
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