Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review.
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| Title: | Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review. |
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| Authors: | Wang, Xiaoyan1 (AUTHOR), Yuan, Ting1 (AUTHOR), Arain, Muhammad Asif2 (AUTHOR), Al‐Rasheed, Mohammed3 (AUTHOR) malrasheed@kfu.edu.sa, Shaukat, Aftab4 (AUTHOR) aftabshaukat40@gmail.com |
| Source: | Food Science & Nutrition. Apr2026, Vol. 14 Issue 4, p1-22. 22p. |
| Subject Terms: | *Livestock, Phytochemicals, Nutritional genomics, Cellular signal transduction, Physiological effects of heat, Oxidative stress, Virtual high-throughput screening (Drug development), Immunoregulation |
| Abstract: | Heat stress (HS) remains a critical environmental constraint threatening the sustainability and productivity of global livestock and poultry production by including oxidative damage, compromising gut integrity, and disruption of immune homeostasis. The limited conventional nutritional strategies in conferring long‐term thermotolerance underscore the urgent need for innovative and biologically effective interventions. In this context, phytobiotics, bioactive plant‐derived compounds, have emerged as promising nutrigenomic modulators due to their potent antioxidant, anti‐inflammatory, antimicrobial, and gut‐protective properties, which collectively reinforce cellular defense mechanisms and enhance physiological adaptability under thermal challenge. This review provides a novel nutrigenomic perspective by elucidating how phytobiotics regulate the expression of key stress‐responsive molecular pathways, including heat shock proteins (HSPs), nuclear factor erythroid 2–related factor 2 (Nrf2), nuclear factor kappa B (NF‐κB), and mitogen‐activated protein kinases (MAPKs), which govern oxidative balance, immune signaling, and apoptosis. Importantly, these mechanistic insights are reinforced by emerging in silico approaches, such as molecular docking and network pharmacology, which offer predictive validation of phytobiotic bioactivity, binding affinities, and target specificity against stress‐related biomarkers, thereby accelerating the identification of high‐potential candidates. By integrating experimental and computational evidence, this review consolidates current knowledge on the genomic and physiological roles of phytobiotics in mitigating HS and associated pathophysiological disturbances, and provides an effective scientific framework for the development of sustainable, phytobiotic‐based nutritional strategies to enhance resilience and productivity in climate‐vulnerable animal production systems. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 193258243 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Xiaoyan%22">Wang, Xiaoyan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Ting%22">Yuan, Ting</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arain%2C+Muhammad+Asif%22">Arain, Muhammad Asif</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al‐Rasheed%2C+Mohammed%22">Al‐Rasheed, Mohammed</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> malrasheed@kfu.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Shaukat%2C+Aftab%22">Shaukat, Aftab</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> aftabshaukat40@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Apr2026, Vol. 14 Issue 4, p1-22. 22p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Livestock%22">Livestock</searchLink><br /><searchLink fieldCode="DE" term="%22Phytochemicals%22">Phytochemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Nutritional+genomics%22">Nutritional genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+heat%22">Physiological effects of heat</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Virtual+high-throughput+screening+%28Drug+development%29%22">Virtual high-throughput screening (Drug development)</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Heat stress (HS) remains a critical environmental constraint threatening the sustainability and productivity of global livestock and poultry production by including oxidative damage, compromising gut integrity, and disruption of immune homeostasis. The limited conventional nutritional strategies in conferring long‐term thermotolerance underscore the urgent need for innovative and biologically effective interventions. In this context, phytobiotics, bioactive plant‐derived compounds, have emerged as promising nutrigenomic modulators due to their potent antioxidant, anti‐inflammatory, antimicrobial, and gut‐protective properties, which collectively reinforce cellular defense mechanisms and enhance physiological adaptability under thermal challenge. This review provides a novel nutrigenomic perspective by elucidating how phytobiotics regulate the expression of key stress‐responsive molecular pathways, including heat shock proteins (HSPs), nuclear factor erythroid 2–related factor 2 (Nrf2), nuclear factor kappa B (NF‐κB), and mitogen‐activated protein kinases (MAPKs), which govern oxidative balance, immune signaling, and apoptosis. Importantly, these mechanistic insights are reinforced by emerging in silico approaches, such as molecular docking and network pharmacology, which offer predictive validation of phytobiotic bioactivity, binding affinities, and target specificity against stress‐related biomarkers, thereby accelerating the identification of high‐potential candidates. By integrating experimental and computational evidence, this review consolidates current knowledge on the genomic and physiological roles of phytobiotics in mitigating HS and associated pathophysiological disturbances, and provides an effective scientific framework for the development of sustainable, phytobiotic‐based nutritional strategies to enhance resilience and productivity in climate‐vulnerable animal production systems. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/fsn3.71788 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 1 Subjects: – SubjectFull: Livestock Type: general – SubjectFull: Phytochemicals Type: general – SubjectFull: Nutritional genomics Type: general – SubjectFull: Cellular signal transduction Type: general – SubjectFull: Physiological effects of heat Type: general – SubjectFull: Oxidative stress Type: general – SubjectFull: Virtual high-throughput screening (Drug development) Type: general – SubjectFull: Immunoregulation Type: general Titles: – TitleFull: Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Xiaoyan – PersonEntity: Name: NameFull: Yuan, Ting – PersonEntity: Name: NameFull: Arain, Muhammad Asif – PersonEntity: Name: NameFull: Al‐Rasheed, Mohammed – PersonEntity: Name: NameFull: Shaukat, Aftab IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20487177 Numbering: – Type: volume Value: 14 – Type: issue Value: 4 Titles: – TitleFull: Food Science & Nutrition Type: main |
| ResultId | 1 |
