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Safety and efficacy of a feed additive consisting of Lactobacillus acidophilusCNCM I‐3231, Ligilactobacillus salivariusCNCM I‐3233, Lacticaseibacillus paracaseiCNCM I‐4901, Bifidobacterium longumCNCM I‐3227 and Bifidobacterium animalis subsp. lactisCNCM I‐3993 (FlorEquilibre® Chat) for cats (WAMINE SAS)

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Title: Safety and efficacy of a feed additive consisting of Lactobacillus acidophilusCNCM I‐3231, Ligilactobacillus salivariusCNCM I‐3233, Lacticaseibacillus paracaseiCNCM I‐4901, Bifidobacterium longumCNCM I‐3227 and Bifidobacterium animalis subsp. lactisCNCM I‐3993 (FlorEquilibre® Chat) for cats (WAMINE SAS)
Authors: Villa, Roberto Edoardo (AUTHOR), Azimonti, Giovanna (AUTHOR), Bonos, Eleftherios (AUTHOR), Christensen, Henrik (AUTHOR), Durjava, Mojca (AUTHOR), Dusemund, Birgit (AUTHOR), Gehring, Ronette (AUTHOR), Glandorf, Boet (AUTHOR), Kouba, Maryline (AUTHOR), López‐Alonso, Marta (AUTHOR), Marcon, Francesca (AUTHOR), Nebbia, Carlo (AUTHOR), Pechová, Alena (AUTHOR), Prieto‐Maradona, Miguel (AUTHOR), Theodoridou, Katerina (AUTHOR), Martelli, Giovanna (AUTHOR), López‐Puente, Secundino (AUTHOR), Saarela, Maria (AUTHOR), Anguita, Montserrat (AUTHOR), Galobart, Jaume (AUTHOR)
Source: EFSA Journal. Apr2026, Vol. 24 Issue 4, p1-11. 11p.
Subject Terms: *Bacteria, Safety, Probiotics, Bifidobacterium longum, Treatment effectiveness, Lactobacillus acidophilus, Cats
Company/Entity: European Food Safety Authority
Abstract: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of FlorEquilibre® Chat when used as a zootechnical additive (functional groups: gut flora stabilisers) for cats. The product under assessment is based on viable cells of Bifidobacterium animalis subsp. lactis CNCM I‐3993, Lactobacillus acidophilus CNCM I‐3231, Ligilactobacillus salivarius CNCM I‐3233, Bifidobacterium longum CNCM I‐3227 and Lacticaseibacillus paracasei CNCM I‐4901. All five strains were suitable for the qualified presumption of safety (QPS) approach to safety assessment. The identity of the strains was established, and no acquired antimicrobial resistance genes were detected, except in B. animalis subsp. lactis CNCM I‐3993. Therefore, the FEEDAP Panel concluded that the use of the strains, except for CNCM I‐3993, is presumed safe for the target species and the environment. The Panel also concluded that the use of B. animalis subsp. lactis CNCM I‐3993 represents a safety concern for the target species, the users and the environment because the strain harbours an acquired antimicrobial resistance gene (tet(W)). Therefore, FlorEquilibre® Chat is considered not safe for the target species, users and the environment. Regarding user safety, FlorEquilibre® Chat is an eye and skin irritant, and a skin and respiratory sensitiser and exposure via any route is considered a risk. Based on the data provided, the Panel cannot conclude on the efficacy of the additive for cats. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety and efficacy of a feed additive consisting of Lactobacillus acidophilusCNCM I‐3231, Ligilactobacillus salivariusCNCM I‐3233, Lacticaseibacillus paracaseiCNCM I‐4901, Bifidobacterium longumCNCM I‐3227 and Bifidobacterium animalis subsp. lactisCNCM I‐3993 (FlorEquilibre® Chat) for cats (WAMINE SAS)
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  Data: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of FlorEquilibre® Chat when used as a zootechnical additive (functional groups: gut flora stabilisers) for cats. The product under assessment is based on viable cells of Bifidobacterium animalis subsp. lactis CNCM I‐3993, Lactobacillus acidophilus CNCM I‐3231, Ligilactobacillus salivarius CNCM I‐3233, Bifidobacterium longum CNCM I‐3227 and Lacticaseibacillus paracasei CNCM I‐4901. All five strains were suitable for the qualified presumption of safety (QPS) approach to safety assessment. The identity of the strains was established, and no acquired antimicrobial resistance genes were detected, except in B. animalis subsp. lactis CNCM I‐3993. Therefore, the FEEDAP Panel concluded that the use of the strains, except for CNCM I‐3993, is presumed safe for the target species and the environment. The Panel also concluded that the use of B. animalis subsp. lactis CNCM I‐3993 represents a safety concern for the target species, the users and the environment because the strain harbours an acquired antimicrobial resistance gene (tet(W)). Therefore, FlorEquilibre® Chat is considered not safe for the target species, users and the environment. Regarding user safety, FlorEquilibre® Chat is an eye and skin irritant, and a skin and respiratory sensitiser and exposure via any route is considered a risk. Based on the data provided, the Panel cannot conclude on the efficacy of the additive for cats. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.2903/j.efsa.2026.10030
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        Text: English
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