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Safety and efficacy of the feed additives consisting of citric acid anhydrous and citric acid monohydrate produced by fermentation with Aspergillus nigerCGMCC 6.466 for all animal species (Sunshine Biotech International).

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Title: Safety and efficacy of the feed additives consisting of citric acid anhydrous and citric acid monohydrate produced by fermentation with Aspergillus nigerCGMCC 6.466 for all animal species (Sunshine Biotech International).
Authors: Villa, Roberto Edoardo (AUTHOR), Azimonti, Giovanna (AUTHOR), Bonos, Eleftherios (AUTHOR), Christensen, Henrik (AUTHOR), Durjava, Mojca (AUTHOR), Dusemund, Birgit (AUTHOR), Gehring, Ronette (AUTHOR), Glandorf, Boet (AUTHOR), Kouba, Maryline (AUTHOR), López‐Alonso, Marta (AUTHOR), Marcon, Francesca (AUTHOR), Nebbia, Carlo (AUTHOR), Pechová, Alena (AUTHOR), Prieto‐Maradona, Miguel (AUTHOR), Theodoridou, Katerina (AUTHOR), Yurkov, Andrey (AUTHOR), Dulak‐Lis, Maria (AUTHOR), Galobart, Jaume (AUTHOR), Vettori, Maria Vittoria (AUTHOR), Villa, Alberto Navarro (AUTHOR)
Source: EFSA Journal. Apr2026, Vol. 24 Issue 4, p1-10. 10p.
Subject Terms: *Toxicology, Feed additives, Safety, Fermentation, Treatment effectiveness, Animal species, Citric acid, Aspergillus niger
Company/Entity: European Food Safety Authority
Abstract: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of citric acid anhydrous and citric acid monohydrate produced by fermentation with Aspergillus niger CGMCC 6.466 as technological feed additives for all animal species. The additives are not currently authorised. Citric acid produced by fermentation with A. niger CGMCC 6.466 may pose safety concerns due to the possible presence of harmful secondary metabolites produced by the production strain. No toxicological studies with the fermentation product were submitted, and the presence of viable cells of the production strain could not be excluded in both forms of the additive. In addition, concerns were raised regarding some processing aids used in the manufacturing process. Therefore, the Panel could not conclude on the safety of citric acid produced with A. niger CGMCC 6.466 for the target species, the consumer and the user. The Panel concludes that the additives are safe for the environment. The FEEDAP Panel concludes that citric acid has the potential to act as an acidity regulator when used in feed and water for all animal species. In the absence of data, the Panel cannot conclude on the efficacy of citric acid as a preservative. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety and efficacy of the feed additives consisting of citric acid anhydrous and citric acid monohydrate produced by fermentation with Aspergillus nigerCGMCC 6.466 for all animal species (Sunshine Biotech International).
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  Data: <searchLink fieldCode="JN" term="%22EFSA+Journal%22">EFSA Journal</searchLink>. Apr2026, Vol. 24 Issue 4, p1-10. 10p.
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  Data: *<searchLink fieldCode="DE" term="%22Toxicology%22">Toxicology</searchLink><br /><searchLink fieldCode="DE" term="%22Feed+additives%22">Feed additives</searchLink><br /><searchLink fieldCode="DE" term="%22Safety%22">Safety</searchLink><br /><searchLink fieldCode="DE" term="%22Fermentation%22">Fermentation</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+species%22">Animal species</searchLink><br /><searchLink fieldCode="DE" term="%22Citric+acid%22">Citric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Aspergillus+niger%22">Aspergillus niger</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22European+Food+Safety+Authority%22">European Food Safety Authority</searchLink>
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  Label: Abstract
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  Data: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of citric acid anhydrous and citric acid monohydrate produced by fermentation with Aspergillus niger CGMCC 6.466 as technological feed additives for all animal species. The additives are not currently authorised. Citric acid produced by fermentation with A. niger CGMCC 6.466 may pose safety concerns due to the possible presence of harmful secondary metabolites produced by the production strain. No toxicological studies with the fermentation product were submitted, and the presence of viable cells of the production strain could not be excluded in both forms of the additive. In addition, concerns were raised regarding some processing aids used in the manufacturing process. Therefore, the Panel could not conclude on the safety of citric acid produced with A. niger CGMCC 6.466 for the target species, the consumer and the user. The Panel concludes that the additives are safe for the environment. The FEEDAP Panel concludes that citric acid has the potential to act as an acidity regulator when used in feed and water for all animal species. In the absence of data, the Panel cannot conclude on the efficacy of citric acid as a preservative. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.2903/j.efsa.2026.10031
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      – Code: eng
        Text: English
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      – SubjectFull: Toxicology
        Type: general
      – SubjectFull: Feed additives
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      – SubjectFull: Safety
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