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Safety and efficacy of a feed additive consisting of vitamin B12 (cyanocobalamin) produced by fermentation with Ensifer adhaerensCCTCC M 20241585 for all animal species (Orffa Additives B.V.).

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Title: Safety and efficacy of a feed additive consisting of vitamin B12 (cyanocobalamin) produced by fermentation with Ensifer adhaerensCCTCC M 20241585 for all animal species (Orffa Additives B.V.).
Authors: Villa, Roberto Edoardo (AUTHOR), Azimonti, Giovanna (AUTHOR), Bonos, Eleftherios (AUTHOR), Christensen, Henrik (AUTHOR), Durjava, Mojca (AUTHOR), Dusemund, Birgit (AUTHOR), Gehring, Ronette (AUTHOR), Glandorf, Boet (AUTHOR), Kouba, Maryline (AUTHOR), López‐Alonso, Marta (AUTHOR), Marcon, Francesca (AUTHOR), Nebbia, Carlo (AUTHOR), Pechová, Alena (AUTHOR), Prieto‐Maradona, Miguel (AUTHOR), Theodoridou, Katerina (AUTHOR), Cocconcelli, Pier Sandro (AUTHOR), Pettenati, Elisa (AUTHOR), Galobart, Jaume (AUTHOR), Vettori, Maria Vittoria (AUTHOR), Valeri, Piera (AUTHOR)
Source: EFSA Journal. Apr2026, Vol. 24 Issue 4, p1-15. 15p.
Subject Terms: *Bacteria, *Animal nutrition, Vitamin B12, Feed additives, Treatment effectiveness, Safety standards, Fermentation
Company/Entity: European Food Safety Authority
Abstract: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B12 (cyanocobalamin) produced by fermentation with Ensifer adhaerens CCTCC M 20241585, when used as a nutritional additive for all animal species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the origin and history of modification of the production strain E. adhaerens CCTCC M 20241585. Although DNA of the production strain was not detected in the product, uncertainties remain regarding the possible presence of its viable cells. Considering the uncertainties on the origin of the cyanocobalamin production strain CTCC M 20241585 and on the possible presence of its viable cells in the additive, the Panel could not conclude on the safety of the additive for the target species, consumer, users and the environment. Cyanocobalamin produced by fermentation with E. adhaerens CCTCC M 20241585 is effective in meeting animal's nutritional requirements when administered via feed. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety and efficacy of a feed additive consisting of vitamin B<subscript>12</subscript> (cyanocobalamin) produced by fermentation with Ensifer adhaerensCCTCC M 20241585 for all animal species (Orffa Additives B.V.).
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  Data: *<searchLink fieldCode="DE" term="%22Bacteria%22">Bacteria</searchLink><br />*<searchLink fieldCode="DE" term="%22Animal+nutrition%22">Animal nutrition</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+B12%22">Vitamin B12</searchLink><br /><searchLink fieldCode="DE" term="%22Feed+additives%22">Feed additives</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Safety+standards%22">Safety standards</searchLink><br /><searchLink fieldCode="DE" term="%22Fermentation%22">Fermentation</searchLink>
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  Data: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B12 (cyanocobalamin) produced by fermentation with Ensifer adhaerens CCTCC M 20241585, when used as a nutritional additive for all animal species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the origin and history of modification of the production strain E. adhaerens CCTCC M 20241585. Although DNA of the production strain was not detected in the product, uncertainties remain regarding the possible presence of its viable cells. Considering the uncertainties on the origin of the cyanocobalamin production strain CTCC M 20241585 and on the possible presence of its viable cells in the additive, the Panel could not conclude on the safety of the additive for the target species, consumer, users and the environment. Cyanocobalamin produced by fermentation with E. adhaerens CCTCC M 20241585 is effective in meeting animal's nutritional requirements when administered via feed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.2903/j.efsa.2026.10049
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        Text: English
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