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Enhanced Bioactivity of Puerariae Radix‐ Hovenia Seed Extracts Through Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Co‐Fermentation: Impact on Alcoholic Liver Injury and Macrophage Polarization.

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Title: Enhanced Bioactivity of Puerariae Radix‐ Hovenia Seed Extracts Through Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Co‐Fermentation: Impact on Alcoholic Liver Injury and Macrophage Polarization.
Authors: Sun, Yunpeng1,2 (AUTHOR), Yao, Shen1 (AUTHOR), Cui, Yuan1 (AUTHOR), Ni, Yiyu1 (AUTHOR), Liu, Meichen1 (AUTHOR), Zhao, Daqing1 (AUTHOR), Yu, Shiting1 (AUTHOR) ysting0331@163.com, Wang, Siming1 (AUTHOR) lwsm126030@126.com
Source: Food Science & Nutrition. May2026, Vol. 14 Issue 5, p1-20. 20p.
Subject Terms: *Bacteria, *Plant extracts, Lactobacillus plantarum, Alcoholic liver diseases, Fermentation, Macrophage activation, Herbal medicine
Abstract: This study investigated the hepatoprotective potential of Puerariae Radix‐Hovenia Seed extracts co‐fermented with Lactiplantibacillus plantarum and Lacticaseibacillus paracasei in alleviating alcoholic liver injury (ALI) and regulating macrophage polarization. Network pharmacology analysis identified 29 core overlapping targets between bioactive components and ALI‐related targets. Co‐fermentation elevated total flavonoids, polysaccharides, and saponins, and altered the flavonoid profile: puerarin (+20%), daidzin (+695%), and myricetin (+84%) increased, while daidzein decreased by 48%. Optimized structural degradation and reduced impurity fragments indicated advantages in enhancing bioavailability and reducing adverse reactions. Co‐fermented extract (PHF) ameliorated alcohol intoxication, activated alcohol‐metabolizing enzymes, reduced blood ethanol and acetaldehyde levels; mitigated hepatotoxicity, hepatosteatosis, and fibrosis. PHF exhibited dual immunomodulatory effects via TLR4/MyD88/NF‐κB pathway by balancing inflammatory cytokines and regulating macrophage polarization. Its natural origin and dual immune properties boost translational potential for ALI. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Enhanced Bioactivity of Puerariae Radix‐ Hovenia Seed Extracts Through Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Co‐Fermentation: Impact on Alcoholic Liver Injury and Macrophage Polarization.
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. May2026, Vol. 14 Issue 5, p1-20. 20p.
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  Data: *<searchLink fieldCode="DE" term="%22Bacteria%22">Bacteria</searchLink><br />*<searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Lactobacillus+plantarum%22">Lactobacillus plantarum</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholic+liver+diseases%22">Alcoholic liver diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Fermentation%22">Fermentation</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophage+activation%22">Macrophage activation</searchLink><br /><searchLink fieldCode="DE" term="%22Herbal+medicine%22">Herbal medicine</searchLink>
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  Label: Abstract
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  Data: This study investigated the hepatoprotective potential of Puerariae Radix‐Hovenia Seed extracts co‐fermented with Lactiplantibacillus plantarum and Lacticaseibacillus paracasei in alleviating alcoholic liver injury (ALI) and regulating macrophage polarization. Network pharmacology analysis identified 29 core overlapping targets between bioactive components and ALI‐related targets. Co‐fermentation elevated total flavonoids, polysaccharides, and saponins, and altered the flavonoid profile: puerarin (+20%), daidzin (+695%), and myricetin (+84%) increased, while daidzein decreased by 48%. Optimized structural degradation and reduced impurity fragments indicated advantages in enhancing bioavailability and reducing adverse reactions. Co‐fermented extract (PHF) ameliorated alcohol intoxication, activated alcohol‐metabolizing enzymes, reduced blood ethanol and acetaldehyde levels; mitigated hepatotoxicity, hepatosteatosis, and fibrosis. PHF exhibited dual immunomodulatory effects via TLR4/MyD88/NF‐κB pathway by balancing inflammatory cytokines and regulating macrophage polarization. Its natural origin and dual immune properties boost translational potential for ALI. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/fsn3.71829
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        Text: English
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      – SubjectFull: Bacteria
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      – SubjectFull: Plant extracts
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      – SubjectFull: Lactobacillus plantarum
        Type: general
      – SubjectFull: Alcoholic liver diseases
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      – SubjectFull: Fermentation
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      – SubjectFull: Macrophage activation
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      – SubjectFull: Herbal medicine
        Type: general
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      – TitleFull: Enhanced Bioactivity of Puerariae Radix‐ Hovenia Seed Extracts Through Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Co‐Fermentation: Impact on Alcoholic Liver Injury and Macrophage Polarization.
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            NameFull: Sun, Yunpeng
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              M: 05
              Text: May2026
              Type: published
              Y: 2026
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