Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.
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| Title: | Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice. |
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| Authors: | Lin, Yuxi1,2 (AUTHOR), Xu, Qingqing3 (AUTHOR), Tang, Siyi1,2 (AUTHOR), Chen, Jingmin1,2 (AUTHOR), Lin, Xing1,2 (AUTHOR), Liu, Yang1,2,4 (AUTHOR) ly18111727129@163.com, Xu, Yuanteng1,2,5 (AUTHOR) xyt973@fjmu.edu.cn |
| Source: | Food Science & Nutrition. Jun2026, Vol. 14 Issue 6, p1-12. 12p. |
| Subject Terms: | Gut microbiota, Intestinal barrier function, Regulatory T cells, Polysaccharides, Cell junctions, Allergic rhinitis |
| Abstract: | Allergic rhinitis (AR) is often exacerbated by antibiotic‐induced gut dysbiosis. This study investigated whether butyrylated starch (BS) could mitigate vancomycin (VAN)‐induced AR aggravation by restoring gut homeostasis. In a murine AR model (n = 5 per group), VAN administration significantly depleted the abundance of butyrate‐producing bacteria (e.g., Clostridia and Lachnospiraceae), suppressed colonic butyrate levels (1.08 ± 0.36 vs. 8.20 ± 0.78 μg/g in controls), and impaired intestinal barrier integrity, thereby worsening nasal symptoms (sneezing frequency: 4.40 ± 1.14 vs. 2.40 ± 0.55 in the AR group). Intervention with BS, a targeted butyrate precursor, effectively reversed these changes by increasing the abundance of butyrogenic taxa, increasing butyrate production (22.86 ± 3.27 μg/g), upregulating the expression of tight junction proteins (Occludin‐1, ZO‐1, and Claudin‐3), and increasing the number of splenic regulatory T (Treg) cells. Our findings demonstrate that BS ameliorates antibiotic‐induced AR via coordinated restoration of the gut microbiota‐barrier‐immune axis, suggesting a novel dietary strategy for the management of allergic inflammation. [ABSTRACT FROM AUTHOR] |
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| Abstract: | Allergic rhinitis (AR) is often exacerbated by antibiotic‐induced gut dysbiosis. This study investigated whether butyrylated starch (BS) could mitigate vancomycin (VAN)‐induced AR aggravation by restoring gut homeostasis. In a murine AR model (n = 5 per group), VAN administration significantly depleted the abundance of butyrate‐producing bacteria (e.g., Clostridia and Lachnospiraceae), suppressed colonic butyrate levels (1.08 ± 0.36 vs. 8.20 ± 0.78 μg/g in controls), and impaired intestinal barrier integrity, thereby worsening nasal symptoms (sneezing frequency: 4.40 ± 1.14 vs. 2.40 ± 0.55 in the AR group). Intervention with BS, a targeted butyrate precursor, effectively reversed these changes by increasing the abundance of butyrogenic taxa, increasing butyrate production (22.86 ± 3.27 μg/g), upregulating the expression of tight junction proteins (Occludin‐1, ZO‐1, and Claudin‐3), and increasing the number of splenic regulatory T (Treg) cells. Our findings demonstrate that BS ameliorates antibiotic‐induced AR via coordinated restoration of the gut microbiota‐barrier‐immune axis, suggesting a novel dietary strategy for the management of allergic inflammation. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20487177 |
| DOI: | 10.1002/fsn3.72000 |
