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Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.

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Title: Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.
Authors: Lin, Yuxi1,2 (AUTHOR), Xu, Qingqing3 (AUTHOR), Tang, Siyi1,2 (AUTHOR), Chen, Jingmin1,2 (AUTHOR), Lin, Xing1,2 (AUTHOR), Liu, Yang1,2,4 (AUTHOR) ly18111727129@163.com, Xu, Yuanteng1,2,5 (AUTHOR) xyt973@fjmu.edu.cn
Source: Food Science & Nutrition. Jun2026, Vol. 14 Issue 6, p1-12. 12p.
Subject Terms: Gut microbiota, Intestinal barrier function, Regulatory T cells, Polysaccharides, Cell junctions, Allergic rhinitis
Abstract: Allergic rhinitis (AR) is often exacerbated by antibiotic‐induced gut dysbiosis. This study investigated whether butyrylated starch (BS) could mitigate vancomycin (VAN)‐induced AR aggravation by restoring gut homeostasis. In a murine AR model (n = 5 per group), VAN administration significantly depleted the abundance of butyrate‐producing bacteria (e.g., Clostridia and Lachnospiraceae), suppressed colonic butyrate levels (1.08 ± 0.36 vs. 8.20 ± 0.78 μg/g in controls), and impaired intestinal barrier integrity, thereby worsening nasal symptoms (sneezing frequency: 4.40 ± 1.14 vs. 2.40 ± 0.55 in the AR group). Intervention with BS, a targeted butyrate precursor, effectively reversed these changes by increasing the abundance of butyrogenic taxa, increasing butyrate production (22.86 ± 3.27 μg/g), upregulating the expression of tight junction proteins (Occludin‐1, ZO‐1, and Claudin‐3), and increasing the number of splenic regulatory T (Treg) cells. Our findings demonstrate that BS ameliorates antibiotic‐induced AR via coordinated restoration of the gut microbiota‐barrier‐immune axis, suggesting a novel dietary strategy for the management of allergic inflammation. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Yuxi%22">Lin, Yuxi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Qingqing%22">Xu, Qingqing</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Siyi%22">Tang, Siyi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jingmin%22">Chen, Jingmin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Xing%22">Lin, Xing</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yang%22">Liu, Yang</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> ly18111727129@163.com</i><br /><searchLink fieldCode="AR" term="%22Xu%2C+Yuanteng%22">Xu, Yuanteng</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<i> xyt973@fjmu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Science+%26+Nutrition%22">Food Science & Nutrition</searchLink>. Jun2026, Vol. 14 Issue 6, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Intestinal+barrier+function%22">Intestinal barrier function</searchLink><br /><searchLink fieldCode="DE" term="%22Regulatory+T+cells%22">Regulatory T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+junctions%22">Cell junctions</searchLink><br /><searchLink fieldCode="DE" term="%22Allergic+rhinitis%22">Allergic rhinitis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Allergic rhinitis (AR) is often exacerbated by antibiotic‐induced gut dysbiosis. This study investigated whether butyrylated starch (BS) could mitigate vancomycin (VAN)‐induced AR aggravation by restoring gut homeostasis. In a murine AR model (n = 5 per group), VAN administration significantly depleted the abundance of butyrate‐producing bacteria (e.g., Clostridia and Lachnospiraceae), suppressed colonic butyrate levels (1.08 ± 0.36 vs. 8.20 ± 0.78 μg/g in controls), and impaired intestinal barrier integrity, thereby worsening nasal symptoms (sneezing frequency: 4.40 ± 1.14 vs. 2.40 ± 0.55 in the AR group). Intervention with BS, a targeted butyrate precursor, effectively reversed these changes by increasing the abundance of butyrogenic taxa, increasing butyrate production (22.86 ± 3.27 μg/g), upregulating the expression of tight junction proteins (Occludin‐1, ZO‐1, and Claudin‐3), and increasing the number of splenic regulatory T (Treg) cells. Our findings demonstrate that BS ameliorates antibiotic‐induced AR via coordinated restoration of the gut microbiota‐barrier‐immune axis, suggesting a novel dietary strategy for the management of allergic inflammation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/fsn3.72000
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      – Code: eng
        Text: English
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        PageCount: 12
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      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Intestinal barrier function
        Type: general
      – SubjectFull: Regulatory T cells
        Type: general
      – SubjectFull: Polysaccharides
        Type: general
      – SubjectFull: Cell junctions
        Type: general
      – SubjectFull: Allergic rhinitis
        Type: general
    Titles:
      – TitleFull: Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice.
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            NameFull: Lin, Yuxi
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            NameFull: Xu, Qingqing
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            NameFull: Tang, Siyi
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            NameFull: Chen, Jingmin
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            NameFull: Lin, Xing
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            NameFull: Liu, Yang
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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