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Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.

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Title: Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.
Authors: Motsinger-Reif, Alison A.1, Balshaw, David M.2, Birnbaum, Linda S.3, Yuxia Cui2, DellaValle, Curt T.4, Dixon, Cinnamon A.5, Iturriaga, Erin6, Jett, David A.7, Miller, Aubrey K.8, Shanmugam, Victoria K.9, Temkin, Sarah M.10, Kwok, Richard K.11 Richard.Kwok@nih.gov
Source: Environmental Health Perspectives. Jun2026, Vol. 134 Issue 2, p124-133. 10p.
Subject Terms: *Environmental health, *Heavy metals, *Environmental monitoring, *Environmental exposure, *Mass spectrometry, *Environmental sciences, Social determinants of health, Artificial intelligence, Wearable technology, Time series analysis, Conceptual structures, Geographic information systems, Life course approach, Individualized medicine, Factor analysis
Company/Entity: National Institutes of Health (U.S.) , European Union
Abstract: BACKGROUND: Exposomics is a conceptual framework positioned at the intersection of environmental health sciences and precision medicine. It seeks to comprehensively understand how environmental exposures and the body’s response to these exposures impact human health across the life course. Introduced in 2005, the exposome concept represents a paradigm shift from single-pollutant studies to an integrated approach considering a broad range of exposures. OBJECTIVES: This commentary explores the ongoing efforts to operationalize the exposome, with a focus on NIH initiatives aimed at building capacity in exposomics research and integrating life-course exposure data into health research. METHODS: This commentary draws on a structured review of current NIH funding opportunities, initiatives, and strategic documents related to exposomics. Key NIH-supported projects and collaborations were identified through an analysis of publicly available agency reports, grant announcements, and program descriptions. Additional insights were gathered from relevant literature and international research activities to contextualize the NIH’s role in promoting exposomics and integrating life-course exposure data into health research. DISCUSSION: Operationalizing the exposome is essential for advancing the field of environmental health and precision medicine. NIH-supported initiatives, alongside international collaborations, aim to standardize methodologies, develop tools, and promote interdisciplinary research. Addressing the complexities of exposomics requires integrating diverse data sets and fostering global coordination, paving the way for innovative strategies to improve human health outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.
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  Data: <searchLink fieldCode="AR" term="%22Motsinger-Reif%2C+Alison+A%2E%22">Motsinger-Reif, Alison A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Balshaw%2C+David+M%2E%22">Balshaw, David M.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Birnbaum%2C+Linda+S%2E%22">Birnbaum, Linda S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yuxia+Cui%22">Yuxia Cui</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22DellaValle%2C+Curt+T%2E%22">DellaValle, Curt T.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Dixon%2C+Cinnamon+A%2E%22">Dixon, Cinnamon A.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Iturriaga%2C+Erin%22">Iturriaga, Erin</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Jett%2C+David+A%2E%22">Jett, David A.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Miller%2C+Aubrey+K%2E%22">Miller, Aubrey K.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Shanmugam%2C+Victoria+K%2E%22">Shanmugam, Victoria K.</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Temkin%2C+Sarah+M%2E%22">Temkin, Sarah M.</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Kwok%2C+Richard+K%2E%22">Kwok, Richard K.</searchLink><relatesTo>11</relatesTo><i> Richard.Kwok@nih.gov</i>
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  Data: *<searchLink fieldCode="DE" term="%22Environmental+health%22">Environmental health</searchLink><br />*<searchLink fieldCode="DE" term="%22Heavy+metals%22">Heavy metals</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+monitoring%22">Environmental monitoring</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br />*<searchLink fieldCode="DE" term="%22Mass+spectrometry%22">Mass spectrometry</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+sciences%22">Environmental sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Social+determinants+of+health%22">Social determinants of health</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+intelligence%22">Artificial intelligence</searchLink><br /><searchLink fieldCode="DE" term="%22Wearable+technology%22">Wearable technology</searchLink><br /><searchLink fieldCode="DE" term="%22Time+series+analysis%22">Time series analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Conceptual+structures%22">Conceptual structures</searchLink><br /><searchLink fieldCode="DE" term="%22Geographic+information+systems%22">Geographic information systems</searchLink><br /><searchLink fieldCode="DE" term="%22Life+course+approach%22">Life course approach</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Factor+analysis%22">Factor analysis</searchLink>
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  Data: BACKGROUND: Exposomics is a conceptual framework positioned at the intersection of environmental health sciences and precision medicine. It seeks to comprehensively understand how environmental exposures and the body’s response to these exposures impact human health across the life course. Introduced in 2005, the exposome concept represents a paradigm shift from single-pollutant studies to an integrated approach considering a broad range of exposures. OBJECTIVES: This commentary explores the ongoing efforts to operationalize the exposome, with a focus on NIH initiatives aimed at building capacity in exposomics research and integrating life-course exposure data into health research. METHODS: This commentary draws on a structured review of current NIH funding opportunities, initiatives, and strategic documents related to exposomics. Key NIH-supported projects and collaborations were identified through an analysis of publicly available agency reports, grant announcements, and program descriptions. Additional insights were gathered from relevant literature and international research activities to contextualize the NIH’s role in promoting exposomics and integrating life-course exposure data into health research. DISCUSSION: Operationalizing the exposome is essential for advancing the field of environmental health and precision medicine. NIH-supported initiatives, alongside international collaborations, aim to standardize methodologies, develop tools, and promote interdisciplinary research. Addressing the complexities of exposomics requires integrating diverse data sets and fostering global coordination, paving the way for innovative strategies to improve human health outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1021/EHP.6c00364
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