Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.
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| Title: | Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood. |
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| Authors: | Hoang, Thanh T.1,2,3,4, Cosin-Tomas, Marta5,6,7, Yunsung Lee8, Monasso, Giulietta9,10, Zongli Xu11, Li, Sebastian Shaobo12, Xuehuo Zeng13, Starling, Anne P.14,15, Reimann, Brigitte16, Röder, Stefan17, Zillich, Lea18, Jima, Dereje D.19,20, Thio, Chris H. L.21, Pesce, Giancarlo22,23, Kersten, Elin T. G.24,25, Breeze, Charles E.26, Burkholder, Adam B.27, Lee, Mikyeong1, Ward, James M.28, BIOS Consortium |
| Source: | Environmental Health Perspectives. Jul2026, Vol. 134 Issue 3, p289-302. 14p. |
| Subject Terms: | Cotinine, Smoking cessation, Prenatal exposure delayed effects, Fatherhood, Research funding, Genome-wide association studies, Epigenomics, Parenting, Descriptive statistics, Meta-analysis, DNA methylation, Longitudinal method, Data analysis software, Passive smoking, Regression analysis, Children |
| Abstract: | BACKGROUND: Maternal sustained smoking during pregnancy is associated with thousands of differentially methylated CpGs in newborns, but impacts of other prenatal tobacco smoking exposures remain unclear. OBJECTIVE: To identify differential DNA methylation in newborns from maternal sustained smoking and less studied prenatal smoking exposures (i.e., maternal exposure to secondhand smoke [SHS] exposure during pregnancy, maternal quitting before pregnancy, paternal smoking around conception, and paternal quitting before pregnancy). METHODS: We conducted a large meta-analysis of prenatal tobacco smoking exposures and epigenome-wide newborn blood DNA methylation through the Pregnancy And Childhood Epigenetics Consortium (PACE). Across 19 cohorts, 11,175 parent-newborn pairs contributed information on at least one prenatal smoking exposure, mostly from questionnaires. Maternal blood or urine cotinine measurements, available in a few studies, provided objective data for maternal SHS and smoking during pregnancy. Primary analyses used Illumina450 K methylation data; secondary analyses in 5 cohorts examined CpGs unique to the EPIC array. RESULTS: Maternal sustained smoking associated with differential DNA methylation (false discovery rate [FDR] < 0.05) at 8,862 CpGs on the 450 K (푛 = 8,148) and did not differ by infant sex. We identified over 300 novel genes not previously identified in EWAS of smoking. No differential methylation was associated with maternal SHS, maternal former smoking, or paternal smoking around conception. However, cg24805739 (MED13L) was associated with former paternal former smoking. Forty-one novel genes were identified using maternal cotinine measurements compared to questionnaire. In EPIC unique analyses (푛 = 3,415), differential methylation was observed with maternal sustained smoking (211 CpGs), maternal SHS (5 CpGs), and paternal former smoking (4 CpGs). Smoking-associated CpGs in blood were strongly enriched for functional elements across multiple tissues. CONCLUSIONS: Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking, and paternal smoking. [ABSTRACT FROM AUTHOR] |
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| Database: | GreenFILE |
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