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Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

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Title: Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator
Authors: Lahm, George P. george.p.lahm@usa.dupont.com, Stevenson, Thomas M.1, Selby, Thomas P.1, Freudenberger, John H.1, Cordova, Daniel1, Flexner, Lindsey1, Bellin, Cheryl A.1, Dubas, Christine M.1, Smith, Ben K.1, Hughes, Kenneth A.1, Hollingshaus, J. Gary1, Clark, Christopher E.1, Benner, Eric A.1
Source: Bioorganic & Medicinal Chemistry Letters. Nov2007, Vol. 17 Issue 22, p6274-6279. 6p.
Subject Terms: *Insecticides, *Pesticides, Ryanodine, Alkaloids
Abstract: Abstract: Rynaxypyr™ is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. [Copyright &y& Elsevier]
Copyright of Bioorganic & Medicinal Chemistry Letters is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubType: Academic Journal
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  Data: Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator
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  Data: <searchLink fieldCode="AR" term="%22Lahm%2C+George+P%2E%22">Lahm, George P.</searchLink><i> george.p.lahm@usa.dupont.com</i><br /><searchLink fieldCode="AR" term="%22Stevenson%2C+Thomas+M%2E%22">Stevenson, Thomas M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Selby%2C+Thomas+P%2E%22">Selby, Thomas P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Freudenberger%2C+John+H%2E%22">Freudenberger, John H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cordova%2C+Daniel%22">Cordova, Daniel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Flexner%2C+Lindsey%22">Flexner, Lindsey</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bellin%2C+Cheryl+A%2E%22">Bellin, Cheryl A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dubas%2C+Christine+M%2E%22">Dubas, Christine M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Smith%2C+Ben+K%2E%22">Smith, Ben K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hughes%2C+Kenneth+A%2E%22">Hughes, Kenneth A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hollingshaus%2C+J%2E+Gary%22">Hollingshaus, J. Gary</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Clark%2C+Christopher+E%2E%22">Clark, Christopher E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Benner%2C+Eric+A%2E%22">Benner, Eric A.</searchLink><relatesTo>1</relatesTo>
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  Data: Bioorganic & Medicinal Chemistry Letters. Nov2007, Vol. 17 Issue 22, p6274-6279. 6p.
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  Data: *<searchLink fieldCode="DE" term="%22Insecticides%22">Insecticides</searchLink><br />*<searchLink fieldCode="DE" term="%22Pesticides%22">Pesticides</searchLink><br /><searchLink fieldCode="DE" term="%22Ryanodine%22">Ryanodine</searchLink><br /><searchLink fieldCode="DE" term="%22Alkaloids%22">Alkaloids</searchLink>
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  Data: Abstract: Rynaxypyr™ is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Bioorganic & Medicinal Chemistry Letters is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=27050453
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              Text: Nov2007
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