Modeling toxic endpoints for improving human health risk assessment of polycyclic aromatic hydrocarbons - parent compounds and simple mixtures.
Saved in:
| Title: | Modeling toxic endpoints for improving human health risk assessment of polycyclic aromatic hydrocarbons - parent compounds and simple mixtures. |
|---|---|
| Authors: | Bruce, E. D.1 erica-bruce@tamu.edu, Autenrieth, R. L.1, Burghardt, R. C.2, Donnelly, K. C.3, McDonald, T. J.3 |
| Source: | Toxicological & Environmental Chemistry. Jan2009, Vol. 91 Issue 1, p137-156. 20p. 2 Charts, 5 Graphs. |
| Subject Terms: | *Polycyclic aromatic hydrocarbons, *Health risk assessment, *Toxicology, *Anthracene, *Mutagenesis, *Carcinogenesis, Biological assay |
| Abstract: | Risk assessments for mixtures of polycyclic aromatic hydrocarbons (PAH) are problematic due to the lack of available potency and toxicity data on individual compounds and mixtures. This article examines the toxicity of parent compounds and designed mixtures of PAH in order to bridge the gap between component assessment and mixture assessment for this class of ubiquitous compounds. The objective for this study was to test seven parent PAH compounds and four PAH mixtures in a set of three bioassays to evaluate the toxicity of parent compound PAH and binary mixtures of PAH. PAH and mixtures were examined in the Salmonella/microsome mutagenicity assay, a Gap Junction Intercellular Communication assay, and the 7-ethoxyresorufin-O-deethylase assay. These assays were chosen for their ability to measure specific toxic endpoints related to the carcinogenic process (i.e. initiation, promotion, and progression). Two compounds similar in structure, benzo(a) pyrene (BAP) and benzanthracene, consistently produced positive results in all three bioassays. Conversely, a linear PAH, anthracene, produced negative results in all three bioassays. An antagonistic response was observed for the mixtures in all three bioassays. Chemical structure was important in explaining the observed responses. Using chemical structure-activity relationships with the steps of the carcinogenic process may be used to improve estimates of toxicity for compounds and mixtures for human health risk assessments. [ABSTRACT FROM AUTHOR] |
| Copyright of Toxicological & Environmental Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: 8gh DbLabel: GreenFILE An: 36623445 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Modeling toxic endpoints for improving human health risk assessment of polycyclic aromatic hydrocarbons - parent compounds and simple mixtures. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bruce%2C+E%2E+D%2E%22">Bruce, E. D.</searchLink><relatesTo>1</relatesTo><i> erica-bruce@tamu.edu</i><br /><searchLink fieldCode="AR" term="%22Autenrieth%2C+R%2E+L%2E%22">Autenrieth, R. L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Burghardt%2C+R%2E+C%2E%22">Burghardt, R. C.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Donnelly%2C+K%2E+C%2E%22">Donnelly, K. C.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22McDonald%2C+T%2E+J%2E%22">McDonald, T. J.</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Toxicological+%26+Environmental+Chemistry%22">Toxicological & Environmental Chemistry</searchLink>. Jan2009, Vol. 91 Issue 1, p137-156. 20p. 2 Charts, 5 Graphs. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Polycyclic+aromatic+hydrocarbons%22">Polycyclic aromatic hydrocarbons</searchLink><br />*<searchLink fieldCode="DE" term="%22Health+risk+assessment%22">Health risk assessment</searchLink><br />*<searchLink fieldCode="DE" term="%22Toxicology%22">Toxicology</searchLink><br />*<searchLink fieldCode="DE" term="%22Anthracene%22">Anthracene</searchLink><br />*<searchLink fieldCode="DE" term="%22Mutagenesis%22">Mutagenesis</searchLink><br />*<searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+assay%22">Biological assay</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Risk assessments for mixtures of polycyclic aromatic hydrocarbons (PAH) are problematic due to the lack of available potency and toxicity data on individual compounds and mixtures. This article examines the toxicity of parent compounds and designed mixtures of PAH in order to bridge the gap between component assessment and mixture assessment for this class of ubiquitous compounds. The objective for this study was to test seven parent PAH compounds and four PAH mixtures in a set of three bioassays to evaluate the toxicity of parent compound PAH and binary mixtures of PAH. PAH and mixtures were examined in the Salmonella/microsome mutagenicity assay, a Gap Junction Intercellular Communication assay, and the 7-ethoxyresorufin-O-deethylase assay. These assays were chosen for their ability to measure specific toxic endpoints related to the carcinogenic process (i.e. initiation, promotion, and progression). Two compounds similar in structure, benzo(a) pyrene (BAP) and benzanthracene, consistently produced positive results in all three bioassays. Conversely, a linear PAH, anthracene, produced negative results in all three bioassays. An antagonistic response was observed for the mixtures in all three bioassays. Chemical structure was important in explaining the observed responses. Using chemical structure-activity relationships with the steps of the carcinogenic process may be used to improve estimates of toxicity for compounds and mixtures for human health risk assessments. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Toxicological & Environmental Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=36623445 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/02772240802028633 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 137 Subjects: – SubjectFull: Polycyclic aromatic hydrocarbons Type: general – SubjectFull: Health risk assessment Type: general – SubjectFull: Toxicology Type: general – SubjectFull: Anthracene Type: general – SubjectFull: Mutagenesis Type: general – SubjectFull: Carcinogenesis Type: general – SubjectFull: Biological assay Type: general Titles: – TitleFull: Modeling toxic endpoints for improving human health risk assessment of polycyclic aromatic hydrocarbons - parent compounds and simple mixtures. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bruce, E. D. – PersonEntity: Name: NameFull: Autenrieth, R. L. – PersonEntity: Name: NameFull: Burghardt, R. C. – PersonEntity: Name: NameFull: Donnelly, K. C. – PersonEntity: Name: NameFull: McDonald, T. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 02772248 Numbering: – Type: volume Value: 91 – Type: issue Value: 1 Titles: – TitleFull: Toxicological & Environmental Chemistry Type: main |
| ResultId | 1 |
