Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study.
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| Title: | Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study. |
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| Authors: | Frederiksen, Marie1,2,3, Vorkamp, Katrin2, Mathiesen, Line1, Mose, Tina1, Knudsen, Lisbeth E.1 l.knudsen@pubhealth.ku.dk |
| Source: | Environmental Health: A Global Access Science Source. 2010, Vol. 9, p32-41. 10p. |
| Subject Terms: | *Polybrominated diphenyl ethers, *Homeostasis, Fireproofing agents, Thyroid hormones, Perfusion |
| Abstract: | Background: Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in consumer products. PBDEs may affect thyroid hormone homeostasis, which can result in irreversible damage of cognitive performance, motor skills and altered behaviour. Thus, in utero exposure is of very high concern due to critical windows in fetal development. Methods: A human ex vivo placenta perfusion system was used to study the kinetics and extent of the placental transfer of BDE-47, BDE-99 and BDE-209 during four-hour perfusions. The PBDEs were added to the maternal circulation and monitored in the maternal and fetal compartments. In addition, the perfused cotyledon, the surrounding placental tissue as well as pre-perfusion placental tissue and umbilical cord plasma were also analysed. The PBDE analysis included Soxhlet extraction, clean-up by adsorption chromatography and GC-MS analysis. Results and Discussion: Placental transfer of BDE-47 was faster and more extensive than for BDE-99. The fetalmaternal ratios (FM-ratio) after four hours of perfusion were 0.47 and 0.25 for BDE-47 and BDE-99, respectively, while the indicative permeability coefficient (IPC) measured after 60 minutes of perfusion was 0.26 h-1 and 0.10 h-1, respectively. The transport of BDE-209 seemed to be limited. These differences between the congeners may be related to the degree of bromination. Significant accumulation was observed for all congeners in the perfused cotyledon as well as in the surrounding placental tissue. Conclusion: The transport of BDE-47 and BDE-99 indicates in utero exposure to these congeners. Although the transport of BDE-209 was limited, however, possible metabolic debromination may lead to products which are both more toxic and transportable. Our study demonstrates fetal exposure to PBDEs, which should be included in risk assessment of PBDE exposure of women of child-bearing age. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 52859246 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Frederiksen%2C+Marie%22">Frederiksen, Marie</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vorkamp%2C+Katrin%22">Vorkamp, Katrin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mathiesen%2C+Line%22">Mathiesen, Line</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mose%2C+Tina%22">Mose, Tina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Knudsen%2C+Lisbeth+E%2E%22">Knudsen, Lisbeth E.</searchLink><relatesTo>1</relatesTo><i> l.knudsen@pubhealth.ku.dk</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 2010, Vol. 9, p32-41. 10p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Polybrominated+diphenyl+ethers%22">Polybrominated diphenyl ethers</searchLink><br />*<searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Fireproofing+agents%22">Fireproofing agents</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroid+hormones%22">Thyroid hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Perfusion%22">Perfusion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in consumer products. PBDEs may affect thyroid hormone homeostasis, which can result in irreversible damage of cognitive performance, motor skills and altered behaviour. Thus, in utero exposure is of very high concern due to critical windows in fetal development. Methods: A human ex vivo placenta perfusion system was used to study the kinetics and extent of the placental transfer of BDE-47, BDE-99 and BDE-209 during four-hour perfusions. The PBDEs were added to the maternal circulation and monitored in the maternal and fetal compartments. In addition, the perfused cotyledon, the surrounding placental tissue as well as pre-perfusion placental tissue and umbilical cord plasma were also analysed. The PBDE analysis included Soxhlet extraction, clean-up by adsorption chromatography and GC-MS analysis. Results and Discussion: Placental transfer of BDE-47 was faster and more extensive than for BDE-99. The fetalmaternal ratios (FM-ratio) after four hours of perfusion were 0.47 and 0.25 for BDE-47 and BDE-99, respectively, while the indicative permeability coefficient (IPC) measured after 60 minutes of perfusion was 0.26 h-1 and 0.10 h-1, respectively. The transport of BDE-209 seemed to be limited. These differences between the congeners may be related to the degree of bromination. Significant accumulation was observed for all congeners in the perfused cotyledon as well as in the surrounding placental tissue. Conclusion: The transport of BDE-47 and BDE-99 indicates in utero exposure to these congeners. Although the transport of BDE-209 was limited, however, possible metabolic debromination may lead to products which are both more toxic and transportable. Our study demonstrates fetal exposure to PBDEs, which should be included in risk assessment of PBDE exposure of women of child-bearing age. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/1476-069X-9-32 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 32 Subjects: – SubjectFull: Polybrominated diphenyl ethers Type: general – SubjectFull: Homeostasis Type: general – SubjectFull: Fireproofing agents Type: general – SubjectFull: Thyroid hormones Type: general – SubjectFull: Perfusion Type: general Titles: – TitleFull: Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Frederiksen, Marie – PersonEntity: Name: NameFull: Vorkamp, Katrin – PersonEntity: Name: NameFull: Mathiesen, Line – PersonEntity: Name: NameFull: Mose, Tina – PersonEntity: Name: NameFull: Knudsen, Lisbeth E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 1476069X Numbering: – Type: volume Value: 9 Titles: – TitleFull: Environmental Health: A Global Access Science Source Type: main |
| ResultId | 1 |
