View in EDS HTML Full Text PDF Full Text

Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception.

Saved in:
Bibliographic Details
Title: Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception.
Authors: Toft, Gunnar1 guntof@rm.dk, Jönsson, Bo A. G.2, Lindh, Christian H.2, Jensen, Tina Kold3, Hjollund, Niels H.4,5, Vested, Anne1, Bonde, Jens Peter6
Source: Environmental Health Perspectives. Mar2012, Vol. 120 Issue 3, p458-463. 6p. 3 Charts.
Subject Terms: *Epidemiology, *Plastics, *Environmental exposure, Chorionic gonadotropins, Confidence intervals, Interviewing, Miscarriage, Questionnaires, Statistical hypothesis testing, Logistic regression analysis, Data analysis, Carbocyclic acids, Data analysis software, Descriptive statistics
Abstract: Background: Animal studies indicate that some phthalate metabolites may harm female reproductive function.Objectives: We assessed the associations between exposure to phthalate metabolites and pregnancy loss.Methods: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, n = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.Results: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).Conclusions: The phthalate metabolite MEHP was associated with higher occurrence of preg­nancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: 8gh
DbLabel: GreenFILE
An: 73745914
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Toft%2C+Gunnar%22">Toft, Gunnar</searchLink><relatesTo>1</relatesTo><i> guntof@rm.dk</i><br /><searchLink fieldCode="AR" term="%22Jönsson%2C+Bo+A%2E+G%2E%22">Jönsson, Bo A. G.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lindh%2C+Christian+H%2E%22">Lindh, Christian H.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jensen%2C+Tina+Kold%22">Jensen, Tina Kold</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hjollund%2C+Niels+H%2E%22">Hjollund, Niels H.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Vested%2C+Anne%22">Vested, Anne</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bonde%2C+Jens+Peter%22">Bonde, Jens Peter</searchLink><relatesTo>6</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Mar2012, Vol. 120 Issue 3, p458-463. 6p. 3 Charts.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br />*<searchLink fieldCode="DE" term="%22Plastics%22">Plastics</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Chorionic+gonadotropins%22">Chorionic gonadotropins</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Miscarriage%22">Miscarriage</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Carbocyclic+acids%22">Carbocyclic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Animal studies indicate that some phthalate metabolites may harm female reproductive function.Objectives: We assessed the associations between exposure to phthalate metabolites and pregnancy loss.Methods: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, n = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.Results: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).Conclusions: The phthalate metabolite MEHP was associated with higher occurrence of preg­nancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=73745914
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/ehp.1103552
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 458
    Subjects:
      – SubjectFull: Epidemiology
        Type: general
      – SubjectFull: Plastics
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Chorionic gonadotropins
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Interviewing
        Type: general
      – SubjectFull: Miscarriage
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Statistical hypothesis testing
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Carbocyclic acids
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
    Titles:
      – TitleFull: Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Toft, Gunnar
      – PersonEntity:
          Name:
            NameFull: Jönsson, Bo A. G.
      – PersonEntity:
          Name:
            NameFull: Lindh, Christian H.
      – PersonEntity:
          Name:
            NameFull: Jensen, Tina Kold
      – PersonEntity:
          Name:
            NameFull: Hjollund, Niels H.
      – PersonEntity:
          Name:
            NameFull: Vested, Anne
      – PersonEntity:
          Name:
            NameFull: Bonde, Jens Peter
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 120
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1