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The Effects of PCB Exposure and Fish Concumption on Endogenous Hormones.

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Title: The Effects of PCB Exposure and Fish Concumption on Endogenous Hormones.
Authors: Persky, Victoria, Turyk, Mary, Anderson, Henry A., Hanrahan, Lawrence P, Falk, Claire, Steenport, Dyan N., Chatterton Jr., Robert, Freels, Sally, Boddy, James, Budd, Marvin, Burkett, Mandy, Fiore, Beth, Humphrey, Harold E.B., Johnson, Robert, Lee, Grace, Monaghan, Susan, Reed, Daniel, Shelley, Tracey, Sonzogni, William
Source: Environmental Health Perspectives. Dec2001, Vol. 109 Issue 12, p1275. 9p. 7 Charts.
Subject Terms: *Polychlorinated biphenyls, Thyroxine, Steroids
Abstract: Previous studies have suggested that exposure to polychlorinated biphenyls (PCBs) may alter thyroid Function, but data on effects of PCB exposure on other endogenous hormones has been lacking. The current study is ancillary to a larger investigation of the effects of Great Lakes fish consumption on PCBs and reproductive function. In the current study we examine associations of PCBs, 1,1-bis (4-chlorophenyl)-2,2-dichloroethene (DDE), and fish consumption with thyroid and steroid hormones in 178 men and PCBs, DDE, and fish consumption with thyroid hormones in 51 women from the original study. Serum PCB level and consumption of Great Lakes fish are associated with significantly lower levels of thyroxine (T[sub4]) and free thyroxine index (FTI) in women and with significantly lower levels of T[sub4] in men. Fish consumption, but not PCB level, is significantly and inversely associated with triiodothyronine (T[sub3]) in men. Results for thyroidstimulating hormone (TSH) are inconsistent. Among men, there are significant inverse associations of both PCB and fish consumption with sex hormone-binding globulin (SHBG)-bound testosterone, but no association with SHBG or free testosterone. There are no significant overall associations of PCB, DDE, or fish consumption with estrone sulfate, follicle-stimulating hormone, luteinizing hormone, or dehydroepiandrosterone sulfate. The results of this study are consistent with previous studies showing effects of fish consumption and PCB exposure on thyroid hormones and suggest that PCBs may also decrease steroid binding to SHBG. Elucidation of specific mechanisms must await future investigations. Key words: consumption, fish, hormones, PCBs, steroid, thyroid. Environ Health Perspect 109:1275-1283 (2001). [Online 30 November 2001] http://ehpnet1.niehs.nih.gov/docs/2001/109p1275-1283persky/abs tract.html [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The Effects of PCB Exposure and Fish Concumption on Endogenous Hormones.
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  Data: <searchLink fieldCode="AR" term="%22Persky%2C+Victoria%22">Persky, Victoria</searchLink><br /><searchLink fieldCode="AR" term="%22Turyk%2C+Mary%22">Turyk, Mary</searchLink><br /><searchLink fieldCode="AR" term="%22Anderson%2C+Henry+A%2E%22">Anderson, Henry A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hanrahan%2C+Lawrence+P%22">Hanrahan, Lawrence P</searchLink><br /><searchLink fieldCode="AR" term="%22Falk%2C+Claire%22">Falk, Claire</searchLink><br /><searchLink fieldCode="AR" term="%22Steenport%2C+Dyan+N%2E%22">Steenport, Dyan N.</searchLink><br /><searchLink fieldCode="AR" term="%22Chatterton+Jr%2E%2C+Robert%22">Chatterton Jr., Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Freels%2C+Sally%22">Freels, Sally</searchLink><br /><searchLink fieldCode="AR" term="%22Boddy%2C+James%22">Boddy, James</searchLink><br /><searchLink fieldCode="AR" term="%22Budd%2C+Marvin%22">Budd, Marvin</searchLink><br /><searchLink fieldCode="AR" term="%22Burkett%2C+Mandy%22">Burkett, Mandy</searchLink><br /><searchLink fieldCode="AR" term="%22Fiore%2C+Beth%22">Fiore, Beth</searchLink><br /><searchLink fieldCode="AR" term="%22Humphrey%2C+Harold+E%2EB%2E%22">Humphrey, Harold E.B.</searchLink><br /><searchLink fieldCode="AR" term="%22Johnson%2C+Robert%22">Johnson, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Grace%22">Lee, Grace</searchLink><br /><searchLink fieldCode="AR" term="%22Monaghan%2C+Susan%22">Monaghan, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Reed%2C+Daniel%22">Reed, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Shelley%2C+Tracey%22">Shelley, Tracey</searchLink><br /><searchLink fieldCode="AR" term="%22Sonzogni%2C+William%22">Sonzogni, William</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Dec2001, Vol. 109 Issue 12, p1275. 9p. 7 Charts.
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  Data: *<searchLink fieldCode="DE" term="%22Polychlorinated+biphenyls%22">Polychlorinated biphenyls</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroxine%22">Thyroxine</searchLink><br /><searchLink fieldCode="DE" term="%22Steroids%22">Steroids</searchLink>
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  Data: Previous studies have suggested that exposure to polychlorinated biphenyls (PCBs) may alter thyroid Function, but data on effects of PCB exposure on other endogenous hormones has been lacking. The current study is ancillary to a larger investigation of the effects of Great Lakes fish consumption on PCBs and reproductive function. In the current study we examine associations of PCBs, 1,1-bis (4-chlorophenyl)-2,2-dichloroethene (DDE), and fish consumption with thyroid and steroid hormones in 178 men and PCBs, DDE, and fish consumption with thyroid hormones in 51 women from the original study. Serum PCB level and consumption of Great Lakes fish are associated with significantly lower levels of thyroxine (T[sub4]) and free thyroxine index (FTI) in women and with significantly lower levels of T[sub4] in men. Fish consumption, but not PCB level, is significantly and inversely associated with triiodothyronine (T[sub3]) in men. Results for thyroidstimulating hormone (TSH) are inconsistent. Among men, there are significant inverse associations of both PCB and fish consumption with sex hormone-binding globulin (SHBG)-bound testosterone, but no association with SHBG or free testosterone. There are no significant overall associations of PCB, DDE, or fish consumption with estrone sulfate, follicle-stimulating hormone, luteinizing hormone, or dehydroepiandrosterone sulfate. The results of this study are consistent with previous studies showing effects of fish consumption and PCB exposure on thyroid hormones and suggest that PCBs may also decrease steroid binding to SHBG. Elucidation of specific mechanisms must await future investigations. Key words: consumption, fish, hormones, PCBs, steroid, thyroid. Environ Health Perspect 109:1275-1283 (2001). [Online 30 November 2001] http://ehpnet1.niehs.nih.gov/docs/2001/109p1275-1283persky/abs tract.html [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1289/ehp.011091275
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        Text: English
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