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Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.

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Title: Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.
Authors: Garlantézec, Ronan1,2,3 ronan.garlantezec@ehesp.fr, Warembourg, Charline1,2, Monfort, Christine1,2, Labat, Laurence4, Pulkkinen, Juha5, Bonvallot, Nathalie1,2,3, Multigner, Luc1,2, Chevrier, Cécile1,2, Cordier, Sylvaine1,2
Source: Environmental Health Perspectives. Oct2013, Vol. 121 Issue 10, p1167-1173. 7p. 1 Diagram, 4 Charts, 1 Graph.
Subject Terms: *Chromatographic analysis, *Epidemiology, Mass spectrometry methodology, Chi-squared test, Confidence intervals, Fisher exact test, Glycols, Pregnancy, Questionnaires, Research funding, Statistical sampling, Statistics, Time, Data analysis, Maximum likelihood statistics, Proportional hazards models, Descriptive statistics
Geographic Terms: France
Abstract: Background: Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. Objective: We examined the relation between women's exposure to glycol ethers and time to pregnancy. Methods: We used chromatography coupled to mass spectrometry to measure eight glycol ether metabolites in urine samples from randomly selected women in the PELAGIE mother-child cohort who had samples collected before 19 weeks of gestation. Using time to pregnancy information collected at the beginning of the pregnancy (women were asked how many months it took for them to conceive), we estimated associations between metabolite levels and time to pregnancy in 519 women with complete data using discrete-time Cox proportional hazards models to adjust for potential confounders. Results: We detected glycol ether metabolites in 6% (for ethoxyacetic acid) to 93% (for phenoxyacetic and butoxyacetic acids) of urine samples. Phenoxyacetic acid was the only metabolite with a statistically significant association with longer time to pregnancy [fecundability OR = 0.82; 95% CI: 0.63, 1.06 for the second and third quartile combined; fecundability OR = 0.70; 95% CI: 0.52, 0.95 for a fourth-quartile (≥ 1.38 mg/L) vs. first-quartile concentration (< 0.14 mg/L)]. This association remained stable after multiple sensitivity analyses. Conclusion: Phenoxyacetic acid, which was present in most of the urine samples tested in our study, was associated with increased time to pregnancy. This metabolite and its main parent com­pound, 2-phenoxyethanol, are plausible causes of decreased fecundability, but they may also be surrogates for potential coexposures to compounds frequently present in cosmetics. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Environmental+Health+Perspectives%22&quot;&gt;Environmental Health Perspectives&lt;/searchLink&gt;. Oct2013, Vol. 121 Issue 10, p1167-1173. 7p. 1 Diagram, 4 Charts, 1 Graph.
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  Data: Background: Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. Objective: We examined the relation between women&#39;s exposure to glycol ethers and time to pregnancy. Methods: We used chromatography coupled to mass spectrometry to measure eight glycol ether metabolites in urine samples from randomly selected women in the PELAGIE mother-child cohort who had samples collected before 19 weeks of gestation. Using time to pregnancy information collected at the beginning of the pregnancy (women were asked how many months it took for them to conceive), we estimated associations between metabolite levels and time to pregnancy in 519 women with complete data using discrete-time Cox proportional hazards models to adjust for potential confounders. Results: We detected glycol ether metabolites in 6% (for ethoxyacetic acid) to 93% (for phenoxyacetic and butoxyacetic acids) of urine samples. Phenoxyacetic acid was the only metabolite with a statistically significant association with longer time to pregnancy [fecundability OR = 0.82; 95% CI: 0.63, 1.06 for the second and third quartile combined; fecundability OR = 0.70; 95% CI: 0.52, 0.95 for a fourth-quartile (≥ 1.38 mg/L) vs. first-quartile concentration (&lt; 0.14 mg/L)]. This association remained stable after multiple sensitivity analyses. Conclusion: Phenoxyacetic acid, which was present in most of the urine samples tested in our study, was associated with increased time to pregnancy. This metabolite and its main parent com&#173;pound, 2-phenoxyethanol, are plausible causes of decreased fecundability, but they may also be surrogates for potential coexposures to compounds frequently present in cosmetics. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1289/ehp.1206103.
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      – SubjectFull: Glycols
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      – SubjectFull: Pregnancy
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