View in EDS HTML Full Text PDF Full Text

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study.

Saved in:
Bibliographic Details
Title: GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study.
Authors: MacIntyre, Elaina A.1,2, Brauer, Michael1, Melén, Erik3,4, Bauer, Carl Peter5, Bauer, Mario6, Berdel, Dietrich7, Bergström, Anna3, Brunekreef, Bert8,9, Chan-Yeung, Moira10, Klümper, Claudia11, Fuertes, Elaine1,2, Gehring, Ulrike8, Gref, Anna3, Heinrich, Joachim2, Herbarth, Olf12, Kerkhof, Marjan13, Koppelman, Gerard H.14, Kozyrskyj, Anita L.15,16, Pershagen, Göran3, Postma, Dirkje S.17,18
Source: Environmental Health Perspectives. Apr2014, Vol. 122 Issue 4, p418-424. 7p. 5 Charts.
Subject Terms: *Air pollution, *Asthma, *Epidemiology, *Nitrogen oxides, *Particulate matter, Genetics of asthma, Chi-squared test, Confidence intervals, Glutathione, Research funding, Statistics, Transferases, Tumor necrosis factors, Data analysis, Data analysis software, Descriptive statistics, Children
Geographic Terms: Canada, Germany, Netherlands, Sweden
Abstract: BACKGROUND: Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE: Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood asthma. METHODS: Traffic-related air pollution, asthma, wheeze, gene variant, and potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma and wheeze from birth to 7-8 years of age (confirmed by pediatric allergist in two cohorts). Individual estimates of annual average air pollution [nitrogen dioxide (NO2), particulate matter ≤ 2.5 μm (PM2.5), PM2.5 absorbance, ozone] were assigned to each child's birth address using land use regression, atmospheric modeling, and ambient monitoring data. Effect modification by variants in GSTP1 (rs1138272/Ala114Val and rs1695/IIe105Val) and TNF (rs1800629/G-308A) was investigated. RESULTS: Data on asthma, wheeze, potential confounders, at least one SNP of interest, and NO2 were available for 5,115 children. GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. In relation to air pollution exposure, children with one or more GSTP1 rs1138272 minor allele were at increased risk of current asthma [odds ratio (OR) = 2.59; 95% CI: 1.43, 4.68 per 10 μg/m3 NO2] and ever asthma (OR = 1.64; 95% CI: 1.06, 2.53) compared with homozygous major allele carriers (OR = 0.95; 95% CI: 0.68, 1.32 for current and OR = 1.20; 95% CI: 0.98, 1.48 for ever asthma; Bonferroni-corrected interaction p = 0.04 and 0.01, respectively). Similarly, for GSTP1 rs1695, associations between NO2 and current and ever asthma had ORs of 1.43 (95% CI: 1.03, 1.98) and 1.36 (95% CI: 1.08, 1.70), respectively, for minor allele carriers compared with ORs of 0.82 (95% CI: 0.52, 1.32) and 1.12 (95% CI: 0.84, 1.49) for homozygous major allele carriers (Bonferroni-corrected interaction p-values 0.48 and 0.09). There were no clear differences by TNF genotype. CONCLUSIONS: Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: 8gh
DbLabel: GreenFILE
An: 95463002
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22MacIntyre%2C+Elaina+A%2E%22">MacIntyre, Elaina A.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Brauer%2C+Michael%22">Brauer, Michael</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Melén%2C+Erik%22">Melén, Erik</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bauer%2C+Carl+Peter%22">Bauer, Carl Peter</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Bauer%2C+Mario%22">Bauer, Mario</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Berdel%2C+Dietrich%22">Berdel, Dietrich</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Bergström%2C+Anna%22">Bergström, Anna</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Brunekreef%2C+Bert%22">Brunekreef, Bert</searchLink><relatesTo>8,9</relatesTo><br /><searchLink fieldCode="AR" term="%22Chan-Yeung%2C+Moira%22">Chan-Yeung, Moira</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Klümper%2C+Claudia%22">Klümper, Claudia</searchLink><relatesTo>11</relatesTo><br /><searchLink fieldCode="AR" term="%22Fuertes%2C+Elaine%22">Fuertes, Elaine</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gehring%2C+Ulrike%22">Gehring, Ulrike</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Gref%2C+Anna%22">Gref, Anna</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Heinrich%2C+Joachim%22">Heinrich, Joachim</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Herbarth%2C+Olf%22">Herbarth, Olf</searchLink><relatesTo>12</relatesTo><br /><searchLink fieldCode="AR" term="%22Kerkhof%2C+Marjan%22">Kerkhof, Marjan</searchLink><relatesTo>13</relatesTo><br /><searchLink fieldCode="AR" term="%22Koppelman%2C+Gerard+H%2E%22">Koppelman, Gerard H.</searchLink><relatesTo>14</relatesTo><br /><searchLink fieldCode="AR" term="%22Kozyrskyj%2C+Anita+L%2E%22">Kozyrskyj, Anita L.</searchLink><relatesTo>15,16</relatesTo><br /><searchLink fieldCode="AR" term="%22Pershagen%2C+Göran%22">Pershagen, Göran</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Postma%2C+Dirkje+S%2E%22">Postma, Dirkje S.</searchLink><relatesTo>17,18</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Apr2014, Vol. 122 Issue 4, p418-424. 7p. 5 Charts.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br />*<searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br />*<searchLink fieldCode="DE" term="%22Nitrogen+oxides%22">Nitrogen oxides</searchLink><br />*<searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics+of+asthma%22">Genetics of asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione%22">Glutathione</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Transferases%22">Transferases</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Canada%22">Canada</searchLink><br /><searchLink fieldCode="DE" term="%22Germany%22">Germany</searchLink><br /><searchLink fieldCode="DE" term="%22Netherlands%22">Netherlands</searchLink><br /><searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE: Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood asthma. METHODS: Traffic-related air pollution, asthma, wheeze, gene variant, and potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma and wheeze from birth to 7-8 years of age (confirmed by pediatric allergist in two cohorts). Individual estimates of annual average air pollution [nitrogen dioxide (NO2), particulate matter ≤ 2.5 μm (PM2.5), PM2.5 absorbance, ozone] were assigned to each child's birth address using land use regression, atmospheric modeling, and ambient monitoring data. Effect modification by variants in GSTP1 (rs1138272/Ala114Val and rs1695/IIe105Val) and TNF (rs1800629/G-308A) was investigated. RESULTS: Data on asthma, wheeze, potential confounders, at least one SNP of interest, and NO2 were available for 5,115 children. GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. In relation to air pollution exposure, children with one or more GSTP1 rs1138272 minor allele were at increased risk of current asthma [odds ratio (OR) = 2.59; 95% CI: 1.43, 4.68 per 10 μg/m3 NO2] and ever asthma (OR = 1.64; 95% CI: 1.06, 2.53) compared with homozygous major allele carriers (OR = 0.95; 95% CI: 0.68, 1.32 for current and OR = 1.20; 95% CI: 0.98, 1.48 for ever asthma; Bonferroni-corrected interaction p = 0.04 and 0.01, respectively). Similarly, for GSTP1 rs1695, associations between NO2 and current and ever asthma had ORs of 1.43 (95% CI: 1.03, 1.98) and 1.36 (95% CI: 1.08, 1.70), respectively, for minor allele carriers compared with ORs of 0.82 (95% CI: 0.52, 1.32) and 1.12 (95% CI: 0.84, 1.49) for homozygous major allele carriers (Bonferroni-corrected interaction p-values 0.48 and 0.09). There were no clear differences by TNF genotype. CONCLUSIONS: Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=95463002
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/ehp.1307459
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 418
    Subjects:
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Asthma
        Type: general
      – SubjectFull: Epidemiology
        Type: general
      – SubjectFull: Nitrogen oxides
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: Genetics of asthma
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Glutathione
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Transferases
        Type: general
      – SubjectFull: Tumor necrosis factors
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Canada
        Type: general
      – SubjectFull: Germany
        Type: general
      – SubjectFull: Netherlands
        Type: general
      – SubjectFull: Sweden
        Type: general
    Titles:
      – TitleFull: GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: MacIntyre, Elaina A.
      – PersonEntity:
          Name:
            NameFull: Brauer, Michael
      – PersonEntity:
          Name:
            NameFull: Melén, Erik
      – PersonEntity:
          Name:
            NameFull: Bauer, Carl Peter
      – PersonEntity:
          Name:
            NameFull: Bauer, Mario
      – PersonEntity:
          Name:
            NameFull: Berdel, Dietrich
      – PersonEntity:
          Name:
            NameFull: Bergström, Anna
      – PersonEntity:
          Name:
            NameFull: Brunekreef, Bert
      – PersonEntity:
          Name:
            NameFull: Chan-Yeung, Moira
      – PersonEntity:
          Name:
            NameFull: Klümper, Claudia
      – PersonEntity:
          Name:
            NameFull: Fuertes, Elaine
      – PersonEntity:
          Name:
            NameFull: Gehring, Ulrike
      – PersonEntity:
          Name:
            NameFull: Gref, Anna
      – PersonEntity:
          Name:
            NameFull: Heinrich, Joachim
      – PersonEntity:
          Name:
            NameFull: Herbarth, Olf
      – PersonEntity:
          Name:
            NameFull: Kerkhof, Marjan
      – PersonEntity:
          Name:
            NameFull: Koppelman, Gerard H.
      – PersonEntity:
          Name:
            NameFull: Kozyrskyj, Anita L.
      – PersonEntity:
          Name:
            NameFull: Pershagen, Göran
      – PersonEntity:
          Name:
            NameFull: Postma, Dirkje S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 122
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1