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Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography.

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Title: Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography.
Authors: Grosjean, Harold1,2, Aimon, Anthony1,3, Hassell‐Hart, Storm4, Thompson, Warren1,3, Koekemoer, Lizbé5,6, Bennett, James5,6, Bradley, Anthony6, Anderson, Cameron2, Wild, Conor1,6, Bradshaw, William J.5, FitzGerald, Edward A.7, Krojer, Tobias6, Fedorov, Oleg6, Biggin, Philip C.2, Spencer, John4,8, j.spencer@sussex.ac.uk, von Delft, Frank1,3,5,6,9, frank.vondelft@cmd.ox.ac.uk
Source: Angewandte Chemie; 4/11/2025, Vol. 137 Issue 16, p1-15, 15p
Database: Applied Science & Technology Source
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