Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists. - Cai, Xianrong; Gao, Liyan; Cheng, Juping; Wang, Yuhe; Liu, Guiying; Ma, Xiaoyan; Fu, Qingquan; Lu, Jingguang; An, Xiaoli; Mu, Zhenqiang (Journal of Computer-Aided Molecular Design, 2026)