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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.

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Title: Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
Authors: Barlaam, Bernard1 bernard.barlaam2@astrazeneca.com, Cosulich, Sabina1, Fitzek, Martina1, Green, Stephen1, Harris, Craig S.2, Hudson, Kevin1, Lambert-van der Brempt, Christine2, Ouvry, Gilles2, Page, Ken1, Ruston, Linette1, Ward, Lara1, Delouvrié, Bénédicte2
Source: Bioorganic & Medicinal Chemistry Letters. Jul2015, Vol. 25 Issue 13, p2679-2685. 7p.
Database: Academic Search Ultimate
Description
ISSN:0960894X
DOI:10.1016/j.bmcl.2015.04.084