A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties.

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Bibliographic Details
Title: A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties.
Authors: Yu, Lei1,2, Huang, Minhao1,2, Xu, Tianfeng1,2, Tong, Linjiang3, Yan, Xiao-e4, Zhang, Zhang1, Xu, Yong1, Yun, Caihong4, Xie, Hua3 hxie@simm.ac.cn, Ding, Ke1,5 ding_ke@gibh.ac.cn, Lu, Xiaoyun5 luxy2016@jnu.edu.cn
Source: European Journal of Medicinal Chemistry. Jan2017, Vol. 126, p1107-1117. 11p.
Database: Academic Search Ultimate
Description
ISSN:02235234
DOI:10.1016/j.ejmech.2016.12.006