A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties.
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| Title: | A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties. |
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| Authors: | Yu, Lei1,2, Huang, Minhao1,2, Xu, Tianfeng1,2, Tong, Linjiang3, Yan, Xiao-e4, Zhang, Zhang1, Xu, Yong1, Yun, Caihong4, Xie, Hua3 hxie@simm.ac.cn, Ding, Ke1,5 ding_ke@gibh.ac.cn, Lu, Xiaoyun5 luxy2016@jnu.edu.cn |
| Source: | European Journal of Medicinal Chemistry. Jan2017, Vol. 126, p1107-1117. 11p. |
| Database: | Academic Search Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: asn DbLabel: Academic Search Ultimate An: 120777266 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yu%2C+Lei%22">Yu, Lei</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Huang%2C+Minhao%22">Huang, Minhao</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Tianfeng%22">Xu, Tianfeng</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tong%2C+Linjiang%22">Tong, Linjiang</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yan%2C+Xiao-e%22">Yan, Xiao-e</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhang%22">Zhang, Zhang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Yong%22">Xu, Yong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yun%2C+Caihong%22">Yun, Caihong</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Xie%2C+Hua%22">Xie, Hua</searchLink><relatesTo>3</relatesTo><i> hxie@simm.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Ding%2C+Ke%22">Ding, Ke</searchLink><relatesTo>1,5</relatesTo><i> ding_ke@gibh.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Lu%2C+Xiaoyun%22">Lu, Xiaoyun</searchLink><relatesTo>5</relatesTo><i> luxy2016@jnu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Medicinal+Chemistry%22">European Journal of Medicinal Chemistry</searchLink>. Jan2017, Vol. 126, p1107-1117. 11p. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=120777266 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejmech.2016.12.006 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1107 Titles: – TitleFull: A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yu, Lei – PersonEntity: Name: NameFull: Huang, Minhao – PersonEntity: Name: NameFull: Xu, Tianfeng – PersonEntity: Name: NameFull: Tong, Linjiang – PersonEntity: Name: NameFull: Yan, Xiao-e – PersonEntity: Name: NameFull: Zhang, Zhang – PersonEntity: Name: NameFull: Xu, Yong – PersonEntity: Name: NameFull: Yun, Caihong – PersonEntity: Name: NameFull: Xie, Hua – PersonEntity: Name: NameFull: Ding, Ke – PersonEntity: Name: NameFull: Lu, Xiaoyun IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 01 Text: Jan2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 02235234 Numbering: – Type: volume Value: 126 Titles: – TitleFull: European Journal of Medicinal Chemistry Type: main |
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