A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties.
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| Title: | A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties. |
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| Authors: | Yu, Lei1,2, Huang, Minhao1,2, Xu, Tianfeng1,2, Tong, Linjiang3, Yan, Xiao-e4, Zhang, Zhang1, Xu, Yong1, Yun, Caihong4, Xie, Hua3 hxie@simm.ac.cn, Ding, Ke1,5 ding_ke@gibh.ac.cn, Lu, Xiaoyun5 luxy2016@jnu.edu.cn |
| Source: | European Journal of Medicinal Chemistry. Jan2017, Vol. 126, p1107-1117. 11p. |
| Database: | Academic Search Ultimate |
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