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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

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Bibliographic Details
Title: Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
Authors: Wagman, Allan S.1, Boyce, Rustum S.1, Brown, Sean P.1, Fang, Eric1, Goff, Dane1, Jansen, Johanna M.1, Le, Vincent P.1, Levine, Barry H.1, Ng, Simon C.1, Zhi-Jie Ni1, Nuss, John M.1, Pfister, Keith B.1, Ramurthy, Savithri1, Renhowe, Paul A.1, Ring, David B.1, Wei Shu1, Subramanian, Sharadha1, Zhou, Xiaohui A.1, Shafer, Cynthia M.1, Harrison, Stephen D.1
Source: Journal of Medicinal Chemistry. 10/26/2017, Vol. 60 Issue 20, p8482-8514. 33p.
Database: Academic Search Ultimate
Description
ISSN:00222623
DOI:10.1021/acs.jmedchem.7b00922