Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection. - Macharia, Gladys N.; Yue, Ling; Staller, Ecco; Dilernia, Dario; Wilkins, Daniel; Song, Heeyah; McGowan, Edward; King, Deborah; Fast, Pat; Imami, Nesrina; Price, Matthew A.; Sanders, Eduard J.; et al. (PLoS Pathogens, 2020)