The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury. - Lebeau, Paul F.; Wassef, Hanny; Jae Hyun Byun; Platko, Khrystyna; Ason, Brandon; Jackson, Simon; Dobroff, Joshua; Shetterly, Susan; Richards, William G.; Al-Hashimi, Ali A.; Doyoon Won, Kevin; Mbikay, Majambu; et al. (Journal of Clinical Investigation, 2021)