Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. - Lin, Xiaoyuan; Fu, Beibei; Xiong, Yan; Xing, Na; Xue, Weiwei; Guo, Dong; Zaky, Mohamed; Pavani, Krishna; Kunec, Dusan; Trimpert, Jakob; Wu, Haibo (PLoS Pathogens, 2023)