Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions. - Nag, Arundhati; Mafi, Amirhossein; Das, Samir; Yu, Mary Beth; Alvarez-Villalonga, Belen; Kim, Soo-Kyung; Su, Yapeng; Goddard III, William A.; Heath, James R. (Communications Chemistry, 2023)