Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex. - Lee, Brenda; Church, Michael; Hokamp, Karsten; Alhussain, Mohamed M.; Bamagoos, Atif A.; Fleming, Alastair B. (PLoS Genetics, 2023)