447 Respiratory status, physical activity, and other measures of wellness before and after introduction of elexacaftor-tezacaftor-ivacaftor in adults with cystic fibrosis using the Alfred Wellness Score. - Button, B.; King, S.; Wilson, L.; Poulsen, M.; Williams, E.; Rang, C.; Kotsimbos, T. (Journal of Cystic Fibrosis, 2023)